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Synthesis of highly substituted tetrahydroquinolines using ethyl cyanoacetate via aza-Michael–Michael addition

A three-component cascade reaction involving 2-alkenyl aniline, aldehydes, and ethyl cyanoacetate in the presence of DBU to synthesize highly substituted 1,2,3,4-tetrahydroquinolines is reported. The reaction proceeded through the Knoevenagel condensation of ethyl cyanoacetate with aldehydes followe...

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Detalles Bibliográficos
Autores principales:	Palanimuthu, Arunan, Chen, Chinpiao, Lee, Gene-Hsian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051536/ https://www.ncbi.nlm.nih.gov/pubmed/35492978 http://dx.doi.org/10.1039/d0ra01264e

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