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A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors

We developed an efficient and environmentally friendly two-step tandem methodology for the synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors. Compared to those observed for other methods, the salient features...

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Autores principales: Du, Li-Hua, Chen, Ping-Feng, Long, Rui-Jie, Xue, Miao, Luo, Xi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051562/
https://www.ncbi.nlm.nih.gov/pubmed/35492096
http://dx.doi.org/10.1039/d0ra00879f
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author Du, Li-Hua
Chen, Ping-Feng
Long, Rui-Jie
Xue, Miao
Luo, Xi-Ping
author_facet Du, Li-Hua
Chen, Ping-Feng
Long, Rui-Jie
Xue, Miao
Luo, Xi-Ping
author_sort Du, Li-Hua
collection PubMed
description We developed an efficient and environmentally friendly two-step tandem methodology for the synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors. Compared to those observed for other methods, the salient features of this work including green reaction conditions, short residence time (50 min), and catalysts are more readily available and the biocatalysis reaction process is efficient and easy to control. This two-step tandem synthesis of coumarin derivatives using the continuous-flow technology is a proof of concept that opens the use of enzymatic microreactors in coumarin derivative biotransformations.
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spelling pubmed-90515622022-04-29 A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors Du, Li-Hua Chen, Ping-Feng Long, Rui-Jie Xue, Miao Luo, Xi-Ping RSC Adv Chemistry We developed an efficient and environmentally friendly two-step tandem methodology for the synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors. Compared to those observed for other methods, the salient features of this work including green reaction conditions, short residence time (50 min), and catalysts are more readily available and the biocatalysis reaction process is efficient and easy to control. This two-step tandem synthesis of coumarin derivatives using the continuous-flow technology is a proof of concept that opens the use of enzymatic microreactors in coumarin derivative biotransformations. The Royal Society of Chemistry 2020-04-02 /pmc/articles/PMC9051562/ /pubmed/35492096 http://dx.doi.org/10.1039/d0ra00879f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Du, Li-Hua
Chen, Ping-Feng
Long, Rui-Jie
Xue, Miao
Luo, Xi-Ping
A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors
title A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors
title_full A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors
title_fullStr A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors
title_full_unstemmed A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors
title_short A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors
title_sort sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme tl im from thermomyces lanuginosus in continuous-flow microreactors
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051562/
https://www.ncbi.nlm.nih.gov/pubmed/35492096
http://dx.doi.org/10.1039/d0ra00879f
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