Synthesis of 1-(β-coumarinyl)-1-(β-indolyl)trifluoroethanols through regioselective Friedel–Crafts alkylation of indoles with β-(trifluoroacetyl)coumarins catalyzed by Sc(OTf)(3)

A highly efficient Friedel–Crafts alkylation of indole derivatives with β-(trifluoroacetyl)coumarins using Sc(OTf)(3) as a catalyst has been developed, which gives regioselective 1,2-adducts to afford 1-(β-coumarinyl)-1-(β-indolyl)trifluoroethanols. A series of tertiary trifluoroethanols containing...

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Detalles Bibliográficos
Autores principales: Shi, Lijun, Liu, Ying, Wang, Caixia, Yuan, Xinxin, Liu, Xiaobiao, Wu, Lulu, Pan, Zhenliang, Yu, Qicheng, Xu, Cuilian, Yang, Guoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051918/
https://www.ncbi.nlm.nih.gov/pubmed/35498470
http://dx.doi.org/10.1039/d0ra01237h

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