An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction

New chiral bicyclic imines, enamines and amines were prepared via Horner–Wadsworth–Emmons reaction of hexahydroquinoxalin-2(1H)-one-derived phosphonate, as the source of a phosphonate carbanion, and a wide range of structurally diverse carbonyl substrates. The simplicity of the synthetic protocol, h...

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Autores principales: Iwanejko, Jakub, Sowiński, Mateusz, Wojaczyńska, Elżbieta, Olszewski, Tomasz K., Górecki, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052066/
https://www.ncbi.nlm.nih.gov/pubmed/35497115
http://dx.doi.org/10.1039/d0ra02646h
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author Iwanejko, Jakub
Sowiński, Mateusz
Wojaczyńska, Elżbieta
Olszewski, Tomasz K.
Górecki, Marcin
author_facet Iwanejko, Jakub
Sowiński, Mateusz
Wojaczyńska, Elżbieta
Olszewski, Tomasz K.
Górecki, Marcin
author_sort Iwanejko, Jakub
collection PubMed
description New chiral bicyclic imines, enamines and amines were prepared via Horner–Wadsworth–Emmons reaction of hexahydroquinoxalin-2(1H)-one-derived phosphonate, as the source of a phosphonate carbanion, and a wide range of structurally diverse carbonyl substrates. The simplicity of the synthetic protocol, high selectivity, and broad substrate scope are the main advantages of the presented methodology.
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spelling pubmed-90520662022-04-29 An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction Iwanejko, Jakub Sowiński, Mateusz Wojaczyńska, Elżbieta Olszewski, Tomasz K. Górecki, Marcin RSC Adv Chemistry New chiral bicyclic imines, enamines and amines were prepared via Horner–Wadsworth–Emmons reaction of hexahydroquinoxalin-2(1H)-one-derived phosphonate, as the source of a phosphonate carbanion, and a wide range of structurally diverse carbonyl substrates. The simplicity of the synthetic protocol, high selectivity, and broad substrate scope are the main advantages of the presented methodology. The Royal Society of Chemistry 2020-04-09 /pmc/articles/PMC9052066/ /pubmed/35497115 http://dx.doi.org/10.1039/d0ra02646h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Iwanejko, Jakub
Sowiński, Mateusz
Wojaczyńska, Elżbieta
Olszewski, Tomasz K.
Górecki, Marcin
An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction
title An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction
title_full An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction
title_fullStr An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction
title_full_unstemmed An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction
title_short An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction
title_sort approach to new chiral bicyclic imines and amines via horner–wadsworth–emmons reaction
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052066/
https://www.ncbi.nlm.nih.gov/pubmed/35497115
http://dx.doi.org/10.1039/d0ra02646h
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