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Risk factors for recurrent intussusception after successful reduction in pediatric patients in a tertiary care hospital of Nepal: A prospective study

BACKGROUND: Intussusception is defined as the invagination of one segment of intestine into another segment of intestine. It may recur because of persistence or return of some factor responsible for the primary intussusception. Various risk factors have been reported but still not well elucidated. M...

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Autores principales: Adhikari, Shankar, Koirala, Dinesh Prasad, Pokhrel, Rameshwor Prasad, Dahal, Geha Raj, Kharel, Sanjeev, Neupane, Subita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052128/
https://www.ncbi.nlm.nih.gov/pubmed/35495376
http://dx.doi.org/10.1016/j.amsu.2022.103427
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author Adhikari, Shankar
Koirala, Dinesh Prasad
Pokhrel, Rameshwor Prasad
Dahal, Geha Raj
Kharel, Sanjeev
Neupane, Subita
author_facet Adhikari, Shankar
Koirala, Dinesh Prasad
Pokhrel, Rameshwor Prasad
Dahal, Geha Raj
Kharel, Sanjeev
Neupane, Subita
author_sort Adhikari, Shankar
collection PubMed
description BACKGROUND: Intussusception is defined as the invagination of one segment of intestine into another segment of intestine. It may recur because of persistence or return of some factor responsible for the primary intussusception. Various risk factors have been reported but still not well elucidated. MATERIALS AND METHODS: This is the prospective observational study. In this study, 78 patients, age <16 years with diagnosis of intussusception between June 2019 and April 2020 who had successful reduction with either hydrostatic reduction and/or operative reduction in Teaching Hospital were enrolled in the study. This is study of early recurrence as patients were followed up to a period of 1 month for recurrence of intussusception. The recurrent cases were thus identified and various variables were compared between recurrent and non-recurrent cases by univariable and multivariable analysis. RESULTS: Among 78 patients, 13 patients (16.7%) had recurrent intussusception. In the univariable analysis model, the significant risk factors for recurrence of intussusception analyzed were duration of symptoms of 48 h or more, fever, blood in stool and palpable mass. While after multivariable analysis, we found that the significant risk factors for recurrence of intussusception were duration of symptoms ≥48 h (OR = 5.32, p-value = 0.047), Fever (OR = 17.32, p-value = 0.001), palpable mass (OR = 24.12, p-value = 0.017). CONCLUSION: Attention and awareness among pediatricians about these sonographic and clinical risk factors especially symptoms for recurrence are needed to minimize pre-hospital delay and identify patients in risk of recurrence. This ultimately helps to improve care for pediatric patients with recurrent intussusception.
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spelling pubmed-90521282022-04-30 Risk factors for recurrent intussusception after successful reduction in pediatric patients in a tertiary care hospital of Nepal: A prospective study Adhikari, Shankar Koirala, Dinesh Prasad Pokhrel, Rameshwor Prasad Dahal, Geha Raj Kharel, Sanjeev Neupane, Subita Ann Med Surg (Lond) Cohort Study BACKGROUND: Intussusception is defined as the invagination of one segment of intestine into another segment of intestine. It may recur because of persistence or return of some factor responsible for the primary intussusception. Various risk factors have been reported but still not well elucidated. MATERIALS AND METHODS: This is the prospective observational study. In this study, 78 patients, age <16 years with diagnosis of intussusception between June 2019 and April 2020 who had successful reduction with either hydrostatic reduction and/or operative reduction in Teaching Hospital were enrolled in the study. This is study of early recurrence as patients were followed up to a period of 1 month for recurrence of intussusception. The recurrent cases were thus identified and various variables were compared between recurrent and non-recurrent cases by univariable and multivariable analysis. RESULTS: Among 78 patients, 13 patients (16.7%) had recurrent intussusception. In the univariable analysis model, the significant risk factors for recurrence of intussusception analyzed were duration of symptoms of 48 h or more, fever, blood in stool and palpable mass. While after multivariable analysis, we found that the significant risk factors for recurrence of intussusception were duration of symptoms ≥48 h (OR = 5.32, p-value = 0.047), Fever (OR = 17.32, p-value = 0.001), palpable mass (OR = 24.12, p-value = 0.017). CONCLUSION: Attention and awareness among pediatricians about these sonographic and clinical risk factors especially symptoms for recurrence are needed to minimize pre-hospital delay and identify patients in risk of recurrence. This ultimately helps to improve care for pediatric patients with recurrent intussusception. Elsevier 2022-04-04 /pmc/articles/PMC9052128/ /pubmed/35495376 http://dx.doi.org/10.1016/j.amsu.2022.103427 Text en © 2022 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Cohort Study
Adhikari, Shankar
Koirala, Dinesh Prasad
Pokhrel, Rameshwor Prasad
Dahal, Geha Raj
Kharel, Sanjeev
Neupane, Subita
Risk factors for recurrent intussusception after successful reduction in pediatric patients in a tertiary care hospital of Nepal: A prospective study
title Risk factors for recurrent intussusception after successful reduction in pediatric patients in a tertiary care hospital of Nepal: A prospective study
title_full Risk factors for recurrent intussusception after successful reduction in pediatric patients in a tertiary care hospital of Nepal: A prospective study
title_fullStr Risk factors for recurrent intussusception after successful reduction in pediatric patients in a tertiary care hospital of Nepal: A prospective study
title_full_unstemmed Risk factors for recurrent intussusception after successful reduction in pediatric patients in a tertiary care hospital of Nepal: A prospective study
title_short Risk factors for recurrent intussusception after successful reduction in pediatric patients in a tertiary care hospital of Nepal: A prospective study
title_sort risk factors for recurrent intussusception after successful reduction in pediatric patients in a tertiary care hospital of nepal: a prospective study
topic Cohort Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052128/
https://www.ncbi.nlm.nih.gov/pubmed/35495376
http://dx.doi.org/10.1016/j.amsu.2022.103427
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