TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report

SCLC transformation in EGFR-mutated lung adenocarcinoma is one of the major phenotypic changes that is observed during the resistance to EGFR tyrosine kinase inhibitors. However, the mechanism of this transformation remains unclear. In this study, we found a small de novo SCLC component in surgicall...

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Detalles Bibliográficos
Autores principales: Kunimasa, Kei, Hirotsu, Yosuke, Amemiya, Kenji, Nakamura, Harumi, Nishino, Kazumi, Honma, Keiichiro, Okami, Jiro, Omata, Masao, Kumagai, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052150/
https://www.ncbi.nlm.nih.gov/pubmed/35498386
http://dx.doi.org/10.1016/j.jtocrr.2022.100305
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author Kunimasa, Kei
Hirotsu, Yosuke
Amemiya, Kenji
Nakamura, Harumi
Nishino, Kazumi
Honma, Keiichiro
Okami, Jiro
Omata, Masao
Kumagai, Toru
author_facet Kunimasa, Kei
Hirotsu, Yosuke
Amemiya, Kenji
Nakamura, Harumi
Nishino, Kazumi
Honma, Keiichiro
Okami, Jiro
Omata, Masao
Kumagai, Toru
author_sort Kunimasa, Kei
collection PubMed
description SCLC transformation in EGFR-mutated lung adenocarcinoma is one of the major phenotypic changes that is observed during the resistance to EGFR tyrosine kinase inhibitors. However, the mechanism of this transformation remains unclear. In this study, we found a small de novo SCLC component in surgically resected specimens of EGFR-mutated lung adenocarcinoma before EGFR tyrosine kinase inhibitor treatment. By using laser microdissection and whole-exome sequencing, TP53 loss of heterozygosity was found to be possibly involved in SCLC transformation.
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spelling pubmed-90521502022-04-30 TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report Kunimasa, Kei Hirotsu, Yosuke Amemiya, Kenji Nakamura, Harumi Nishino, Kazumi Honma, Keiichiro Okami, Jiro Omata, Masao Kumagai, Toru JTO Clin Res Rep Case Report SCLC transformation in EGFR-mutated lung adenocarcinoma is one of the major phenotypic changes that is observed during the resistance to EGFR tyrosine kinase inhibitors. However, the mechanism of this transformation remains unclear. In this study, we found a small de novo SCLC component in surgically resected specimens of EGFR-mutated lung adenocarcinoma before EGFR tyrosine kinase inhibitor treatment. By using laser microdissection and whole-exome sequencing, TP53 loss of heterozygosity was found to be possibly involved in SCLC transformation. Elsevier 2022-03-19 /pmc/articles/PMC9052150/ /pubmed/35498386 http://dx.doi.org/10.1016/j.jtocrr.2022.100305 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kunimasa, Kei
Hirotsu, Yosuke
Amemiya, Kenji
Nakamura, Harumi
Nishino, Kazumi
Honma, Keiichiro
Okami, Jiro
Omata, Masao
Kumagai, Toru
TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report
title TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report
title_full TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report
title_fullStr TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report
title_full_unstemmed TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report
title_short TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report
title_sort tp53 loss of heterozygosity induces de novo sclc formation in egfr-mutated lung adenocarcinoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052150/
https://www.ncbi.nlm.nih.gov/pubmed/35498386
http://dx.doi.org/10.1016/j.jtocrr.2022.100305
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