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Accessibility of ENaC extracellular domain central core residues

The epithelial Na(+) channel (ENaC)/degenerin family has a similar extracellular architecture, where specific regulatory factors interact and alter channel gating behavior. The extracellular palm domain serves as a key link to the channel pore. In this study, we used cysteine-scanning mutagenesis to...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Wang, Xueqi, Chen, Jingxin, Kleyman, Thomas R., Sheng, Shaohu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052164/
https://www.ncbi.nlm.nih.gov/pubmed/35339489
http://dx.doi.org/10.1016/j.jbc.2022.101860