Cargando…
Accessibility of ENaC extracellular domain central core residues
The epithelial Na(+) channel (ENaC)/degenerin family has a similar extracellular architecture, where specific regulatory factors interact and alter channel gating behavior. The extracellular palm domain serves as a key link to the channel pore. In this study, we used cysteine-scanning mutagenesis to...
Autores principales: | Zhang, Lei, Wang, Xueqi, Chen, Jingxin, Kleyman, Thomas R., Sheng, Shaohu |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052164/ https://www.ncbi.nlm.nih.gov/pubmed/35339489 http://dx.doi.org/10.1016/j.jbc.2022.101860 |
Ejemplares similares
-
ENaC in Salt-Sensitive Hypertension: Kidney and Beyond
por: Pitzer, Ashley L., et al.
Publicado: (2020) -
The N terminus of α-ENaC mediates ENaC cleavage and activation by furin
por: Kota, Pradeep, et al.
Publicado: (2018) -
ENaC activation by proteases
por: Anand, Deepika, et al.
Publicado: (2022) -
Extracellular intersubunit interactions modulate epithelial Na(+) channel gating
por: Zhang, Lei, et al.
Publicado: (2023) -
Shear force sensing of epithelial Na(+) channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC
por: Knoepp, Fenja, et al.
Publicado: (2020)