Comparison of postoperative pancreatic fistula between open and laparoscopic surgery in patients with gastric cancer: A meta-analysis

BACKGROUND: Open gastrectomy“OG” compared with laparoscopic gastrectomy“LG” in patients with gastric cancer“GC” has been widely discussed over the past years. However, the lack of comparative analysis in postoperative pancreatic fistula “POPF” hinders its severity as surgical procedures developed rapidly. Therefore, there are still moot on whether one of these surgical options is superior in POPF. OBJECTIVE: To compare the incidence of POPF in patients undergoing OG and LG for gastric cancer “GC”. METHODS: Articles from January 2011 to August 2021 that compared LG and OG for GC were reviewed. Cohort studies were included in our study. The quality of enrolled studies was evaluated. Outcomes regarding POPF complication and relative operation results were analyzed. Statistical analysis portrayed the Weighted mean difference“WMD”and the odds ratio“OR”with a 95% confidence interval “CI”. The curative effect was analyzed using RevMan 5.4.1 software. RESULTS: Totally 7 articles met the inclusion criteria, including 3194 patients with treatment of gastrectomy surgeries for gastric cancer “GC”. There was no significant difference observed in POPF incidence (OR, 95% CI = 1.04 [0.74,1.46], P = 0.81) between OG group and LG group in patients undergoing GC gastrectomy. CONCLUSION: We stringently explored the current incidence of POPF after GC gastrectomy, comparing its incidence during LG and OG, there was no significant difference between OG and LG in the incidence of POPF, and surgeons should give more concern for improvement in surgical techniques. Further research is still needed to explore the risk of causes and surgical techniques should be considered cautiously in a clinical procedure.