Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.

Three new highly oxygenated pimarane diterpenoids, sarcosenones A–C (1–3), and the known 9α-hydroxy-1,8(14),15-isopimaratrien-3,7,11-trione (4), were isolated from cultures of an endolichenic fungus Sarcosomataceae sp. Their structures were elucidated based on NMR spectroscopic data and electronic c...

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Detalles Bibliográficos
Autores principales: Hou, Xintong, Xu, Yang, Zhu, Shuaiming, Zhang, Yang, Guo, Liangdong, Qiu, Feng, Che, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052384/
https://www.ncbi.nlm.nih.gov/pubmed/35495431
http://dx.doi.org/10.1039/d0ra02485f
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author Hou, Xintong
Xu, Yang
Zhu, Shuaiming
Zhang, Yang
Guo, Liangdong
Qiu, Feng
Che, Yongsheng
author_facet Hou, Xintong
Xu, Yang
Zhu, Shuaiming
Zhang, Yang
Guo, Liangdong
Qiu, Feng
Che, Yongsheng
author_sort Hou, Xintong
collection PubMed
description Three new highly oxygenated pimarane diterpenoids, sarcosenones A–C (1–3), and the known 9α-hydroxy-1,8(14),15-isopimaratrien-3,7,11-trione (4), were isolated from cultures of an endolichenic fungus Sarcosomataceae sp. Their structures were elucidated based on NMR spectroscopic data and electronic circular dichroism (ECD) calculations. Compound 1 showed moderate cytotoxicity against a small panel of four human tumor cell lines, with IC(50) values of 7.5–26.4 μM.
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spelling pubmed-90523842022-04-29 Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp. Hou, Xintong Xu, Yang Zhu, Shuaiming Zhang, Yang Guo, Liangdong Qiu, Feng Che, Yongsheng RSC Adv Chemistry Three new highly oxygenated pimarane diterpenoids, sarcosenones A–C (1–3), and the known 9α-hydroxy-1,8(14),15-isopimaratrien-3,7,11-trione (4), were isolated from cultures of an endolichenic fungus Sarcosomataceae sp. Their structures were elucidated based on NMR spectroscopic data and electronic circular dichroism (ECD) calculations. Compound 1 showed moderate cytotoxicity against a small panel of four human tumor cell lines, with IC(50) values of 7.5–26.4 μM. The Royal Society of Chemistry 2020-04-22 /pmc/articles/PMC9052384/ /pubmed/35495431 http://dx.doi.org/10.1039/d0ra02485f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Hou, Xintong
Xu, Yang
Zhu, Shuaiming
Zhang, Yang
Guo, Liangdong
Qiu, Feng
Che, Yongsheng
Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.
title Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.
title_full Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.
title_fullStr Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.
title_full_unstemmed Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.
title_short Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.
title_sort sarcosenones a–c, highly oxygenated pimarane diterpenoids from an endolichenic fungus sarcosomataceae sp.
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052384/
https://www.ncbi.nlm.nih.gov/pubmed/35495431
http://dx.doi.org/10.1039/d0ra02485f
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