pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation

Retinoblastoma (Rb) is a childhood cancer of the developing retina, accounting for up to 17% of all tumors in infancy. To gain insights into the transcriptional events of cell state transitions during Rb development, we established 2 disease models via retinal organoid differentiation of a pRB (reti...

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Detalles Bibliográficos
Autores principales: Rozanska, Agata, Cerna-Chavez, Rodrigo, Queen, Rachel, Collin, Joseph, Zerti, Darin, Dorgau, Birthe, Beh, Chia Shyan, Davey, Tracey, Coxhead, Jonathan, Hussain, Rafiqul, Al-Aama, Jumana, Steel, David H, Benvenisty, Nissim, Armstrong, Lyle, Parulekar, Manoj, Lako, Majlinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Pluripotent Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052432/
https://www.ncbi.nlm.nih.gov/pubmed/35325233
http://dx.doi.org/10.1093/stcltm/szac008

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