A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery

Polymeric microneedles (MNs) are attractive transdermal drug delivery systems because of their efficient drug delivery and minimal invasiveness. Master template fabrication is the most time-consuming and costly step in producing polymeric MNs using a micromoulding approach. Herein, this issue is add...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yongli, Xian, Yiwen, Carrier, Andrew J., Youden, Brian, Servos, Mark, Cui, Shufen, Luan, Tiangang, Lin, Sujing, Zhang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052519/
https://www.ncbi.nlm.nih.gov/pubmed/35495428
http://dx.doi.org/10.1039/d0ra01382j
_version_ 1784696800318324736
author Chen, Yongli
Xian, Yiwen
Carrier, Andrew J.
Youden, Brian
Servos, Mark
Cui, Shufen
Luan, Tiangang
Lin, Sujing
Zhang, Xu
author_facet Chen, Yongli
Xian, Yiwen
Carrier, Andrew J.
Youden, Brian
Servos, Mark
Cui, Shufen
Luan, Tiangang
Lin, Sujing
Zhang, Xu
author_sort Chen, Yongli
collection PubMed
description Polymeric microneedles (MNs) are attractive transdermal drug delivery systems because of their efficient drug delivery and minimal invasiveness. Master template fabrication is the most time-consuming and costly step in producing polymeric MNs using a micromoulding approach. Herein, this issue is addressed by modifying tattoo needle cartridges by adjusting the volume of a PDMS spacer, thus streamlining polymeric MN fabrication and significantly reducing its manufacturing cost. Using the fabricated master template, dissolvable polymeric MN systems containing poly(vinyl pyrrolidone) (PVP) and poly(vinyl alcohol) (PVA) were developed. This MN system exhibits several advantages, including controllable MN length, uniform distribution of each needle, and controllable drug release profiles. Overall, polymeric MN fabrication using this method is inexpensive, simple, and yields controllable and effective transdermal drug delivery.
format Online
Article
Text
id pubmed-9052519
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90525192022-04-29 A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery Chen, Yongli Xian, Yiwen Carrier, Andrew J. Youden, Brian Servos, Mark Cui, Shufen Luan, Tiangang Lin, Sujing Zhang, Xu RSC Adv Chemistry Polymeric microneedles (MNs) are attractive transdermal drug delivery systems because of their efficient drug delivery and minimal invasiveness. Master template fabrication is the most time-consuming and costly step in producing polymeric MNs using a micromoulding approach. Herein, this issue is addressed by modifying tattoo needle cartridges by adjusting the volume of a PDMS spacer, thus streamlining polymeric MN fabrication and significantly reducing its manufacturing cost. Using the fabricated master template, dissolvable polymeric MN systems containing poly(vinyl pyrrolidone) (PVP) and poly(vinyl alcohol) (PVA) were developed. This MN system exhibits several advantages, including controllable MN length, uniform distribution of each needle, and controllable drug release profiles. Overall, polymeric MN fabrication using this method is inexpensive, simple, and yields controllable and effective transdermal drug delivery. The Royal Society of Chemistry 2020-04-20 /pmc/articles/PMC9052519/ /pubmed/35495428 http://dx.doi.org/10.1039/d0ra01382j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Chen, Yongli
Xian, Yiwen
Carrier, Andrew J.
Youden, Brian
Servos, Mark
Cui, Shufen
Luan, Tiangang
Lin, Sujing
Zhang, Xu
A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery
title A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery
title_full A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery
title_fullStr A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery
title_full_unstemmed A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery
title_short A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery
title_sort simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052519/
https://www.ncbi.nlm.nih.gov/pubmed/35495428
http://dx.doi.org/10.1039/d0ra01382j
work_keys_str_mv AT chenyongli asimpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT xianyiwen asimpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT carrierandrewj asimpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT youdenbrian asimpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT servosmark asimpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT cuishufen asimpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT luantiangang asimpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT linsujing asimpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT zhangxu asimpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT chenyongli simpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT xianyiwen simpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT carrierandrewj simpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT youdenbrian simpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT servosmark simpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT cuishufen simpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT luantiangang simpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT linsujing simpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery
AT zhangxu simpleandcosteffectiveapproachtofabricatetunablelengthpolymericmicroneedlepatchesforcontrollabletransdermaldrugdelivery

Ejemplares similares