Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold

Tumor-binding peptides such as human epidermal growth factor receptor 2 (HER2)-binding peptides are attractive therapeutic and diagnostic options for cancer. However, the HER2-binding peptides (HBPs) developed thus far are susceptible to proteolysis and lose their affinity to HER2 in vivo. In this r...

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Detalles Bibliográficos
Autores principales: Yimchuen, Wanaporn, Kadonosono, Tetsuya, Ota, Yumi, Sato, Shinichi, Kitazawa, Maika, Shiozawa, Tadashi, Kuchimaru, Takahiro, Taki, Masumi, Ito, Yuji, Nakamura, Hiroyuki, Kizaka-Kondoh, Shinae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052545/
https://www.ncbi.nlm.nih.gov/pubmed/35495466
http://dx.doi.org/10.1039/d0ra00427h

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