Cargando…

FGFR1 is a potential therapeutic target in neuroblastoma

BACKGROUND: FGFR1 regulates cell–cell adhesion and extracellular matrix architecture and acts as oncogene in several cancers. Potential cancer driver mutations of FGFR1 occur in neuroblastoma (NB), a neural crest-derived pediatric tumor arising in sympathetic nervous system, but so far they have not...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cimmino, Flora, Montella, Annalaura, Tirelli, Matilde, Avitabile, Marianna, Lasorsa, Vito Alessandro, Visconte, Feliciano, Cantalupo, Sueva, Maiorino, Teresa, De Angelis, Biagio, Morini, Martina, Castellano, Aurora, Locatelli, Franco, Capasso, Mario, Iolascon, Achille
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052553/ https://www.ncbi.nlm.nih.gov/pubmed/35488346 http://dx.doi.org/10.1186/s12935-022-02587-x

Ejemplares similares

Functional characterization of full-length BARD1 strengthens its role as a tumor suppressor in neuroblastoma
por: Cimmino, Flora, et al.
Publicado: (2020)

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia
por: Cimmino, Flora, et al.
Publicado: (2019)

Genetic Predisposition to Solid Pediatric Cancers
por: Capasso, Mario, et al.
Publicado: (2020)

Association of PARP1 polymorphisms with response to chemotherapy in patients with high‐risk neuroblastoma
por: Avitabile, Marianna, et al.
Publicado: (2020)

Single-cell transcriptomics of neuroblastoma identifies chemoresistance-associated genes and pathways
por: Avitabile, Marianna, et al.
Publicado: (2022)

CFDP1 is a neuroblastoma susceptibility gene that regulates transcription factors of the noradrenergic cell identity
por: Formicola, Daniela, et al.
Publicado: (2022)

Exploring Shared Susceptibility between Two Neural Crest Cells Originating Conditions: Neuroblastoma and Congenital Heart Disease
por: Testori, Alessandro, et al.
Publicado: (2019)

A Targeted Gene Panel for Circulating Tumor DNA Sequencing in Neuroblastoma
por: Cimmino, Flora, et al.
Publicado: (2020)

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis
por: Lasorsa, Vito Alessandro, et al.
Publicado: (2020)

Inherited rare variants in homologous recombination and neurodevelopmental genes are associated with increased risk of neuroblastoma
por: Bonfiglio, Ferdinando, et al.
Publicado: (2022)

Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells
por: Cimmino, Flora, et al.
Publicado: (2015)

Phenotyping neuroblastoma cells through intelligent scrutiny of stain-free biomarkers in holographic flow cytometry
por: Pirone, Daniele, et al.
Publicado: (2023)

Stain-free identification of cell nuclei using tomographic phase microscopy in flow cytometry
por: Pirone, Daniele, et al.
Publicado: (2022)

An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma
por: Formicola, Daniela, et al.
Publicado: (2016)

A comprehensive characterization of rare mitochondrial DNA variants in neuroblastoma
por: Calabrese, Francesco Maria, et al.
Publicado: (2016)

Kinome multigenic panel identified novel druggable EPHB4‐V871I somatic variant in high‐risk neuroblastoma
por: Andolfo, Immacolata, et al.
Publicado: (2020)

Impact of Interleukin-6 –174 G>C Gene Promoter Polymorphism on Neuroblastoma
por: Totaro, Francesca, et al.
Publicado: (2013)

CD55 is a HIF-2α marker with anti-adhesive and pro-invading properties in neuroblastoma
por: Cimmino, F, et al.
Publicado: (2016)

Therapeutic Targeting of ALK in Neuroblastoma: Experience of Italian Precision Medicine in Pediatric Oncology
por: Pastorino, Fabio, et al.
Publicado: (2023)

Exome and deep sequencing of clinically aggressive neuroblastoma reveal somatic mutations that affect key pathways involved in cancer progression
por: Lasorsa, Vito Alessandro, et al.
Publicado: (2016)

Genetic Analysis of the Coronavirus SARS-CoV-2 Host Protease TMPRSS2 in Different Populations
por: Russo, Roberta, et al.
Publicado: (2020)

Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19
por: Andolfo, Immacolata, et al.
Publicado: (2021)

The TNFRSF13C H159Y Variant Is Associated with Severe COVID-19: A Retrospective Study of 500 Patients from Southern Italy
por: Russo, Roberta, et al.
Publicado: (2021)

Regulatory Noncoding and Predicted Pathogenic Coding Variants of CCR5 Predispose to Severe COVID-19
por: Cantalupo, Sueva, et al.
Publicado: (2021)

Italian Precision Medicine in Pediatric Oncology: Moving beyond Actionable Alterations
por: Pastorino, Fabio, et al.
Publicado: (2022)

Gene Expression Signature of Acquired Chemoresistance in Neuroblastoma Cells
por: Jemaà, Mohamed, et al.
Publicado: (2020)

Germline rare variants of lectin pathway genes predispose to asymptomatic SARS-CoV-2 infection in elderly individuals
por: D’Alterio, Giuseppe, et al.
Publicado: (2022)

The functional variant rs34330 of CDKN1B is associated with risk of neuroblastoma
por: Capasso, Mario, et al.
Publicado: (2017)

Label-free liquid biopsy through the identification of tumor cells by machine learning-powered tomographic phase imaging flow cytometry
por: Pirone, Daniele, et al.
Publicado: (2023)

Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma
por: Quintarelli, Concetta, et al.
Publicado: (2018)

Discovery of epi-Enprioline as a Novel Drug for the Treatment of Vincristine Resistant Neuroblastoma
por: Sime, Wondossen, et al.
Publicado: (2020)

BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma
por: Sime, Wondossen, et al.
Publicado: (2018)

Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma
por: Tumino, Nicola, et al.
Publicado: (2021)

Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma
por: McDaniel, Lee D., et al.
Publicado: (2017)

Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma
por: Diskin, Sharon J, et al.
Publicado: (2012)

Molecular Genetics in Neuroblastoma Prognosis
por: Lerone, Margherita, et al.
Publicado: (2021)

Oncogenic FGFR1 mutation and amplification in common cellular origin in a composite tumor with neuroblastoma and pheochromocytoma
por: Tasaka, Keiji, et al.
Publicado: (2022)

New Insights in 9q21.13 Microdeletion Syndrome: Genotype–Phenotype Correlation of 28 Patients
por: De Falco, Alessandro, et al.
Publicado: (2023)

Dualistic Role of BARD1 in Cancer
por: Cimmino, Flora, et al.
Publicado: (2017)

Effects of PI3K and FGFR inhibitors alone and in combination, and with/without cytostatics in childhood neuroblastoma cell lines
por: Holzhauser, Stefan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f9953vq36oj1r387jkcl8e2lc8