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Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation

INTRODUCTION: Hematopoietic stem cell transplantation (HSCT) is the essential and often the only curative therapeutic option in high risk and relapsed pediatric acute lymphoblastic leukemia (ALL). METHODS: The objective of the study was to investigate whole-genome expression in children with high ri...

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Autores principales: Kwiecinska, Kinga, Strojny, Wojciech, Bik-Multanowski, Miroslaw, Michal Korostynski, Piechota, Marcin, Balwierz, Walentyna, Szymon Skoczen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052811/
https://www.ncbi.nlm.nih.gov/pubmed/35470705
http://dx.doi.org/10.1177/10732748211064776
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author Kwiecinska, Kinga
Strojny, Wojciech
Bik-Multanowski, Miroslaw
Michal Korostynski,
Piechota, Marcin
Balwierz, Walentyna
Szymon Skoczen,
author_facet Kwiecinska, Kinga
Strojny, Wojciech
Bik-Multanowski, Miroslaw
Michal Korostynski,
Piechota, Marcin
Balwierz, Walentyna
Szymon Skoczen,
author_sort Kwiecinska, Kinga
collection PubMed
description INTRODUCTION: Hematopoietic stem cell transplantation (HSCT) is the essential and often the only curative therapeutic option in high risk and relapsed pediatric acute lymphoblastic leukemia (ALL). METHODS: The objective of the study was to investigate whole-genome expression in children with high risk or relapsed ALL referred for HSCT. Gene expression was assessed in 18 children with ALL referred for HSCT (10 high risk, 8 relapsed; median age of 9.4 years) and in a control group of 38 obese children (median age of 14.1 years). Whole-genome expression was assessed in leukocytes using GeneChip® HumanGene 1.0 ST microarray. RESULTS: The analysis of genomic profiles revealed a significantly lower expression of 21 genes with a defined function, involved in immunoglobulin production, lymphocyte function, or regulation of DNA processing in ALL patients referred for HSCT compared with the control group. CONCLUSION: Genome expression of patients with ALL in remission referred to HSCT revealed deep immunosuppression of both B-cell and T-cell lineages, which may increase the probability of donor cell engraftment.
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spelling pubmed-90528112022-04-30 Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation Kwiecinska, Kinga Strojny, Wojciech Bik-Multanowski, Miroslaw Michal Korostynski, Piechota, Marcin Balwierz, Walentyna Szymon Skoczen, Cancer Control Original Research Article INTRODUCTION: Hematopoietic stem cell transplantation (HSCT) is the essential and often the only curative therapeutic option in high risk and relapsed pediatric acute lymphoblastic leukemia (ALL). METHODS: The objective of the study was to investigate whole-genome expression in children with high risk or relapsed ALL referred for HSCT. Gene expression was assessed in 18 children with ALL referred for HSCT (10 high risk, 8 relapsed; median age of 9.4 years) and in a control group of 38 obese children (median age of 14.1 years). Whole-genome expression was assessed in leukocytes using GeneChip® HumanGene 1.0 ST microarray. RESULTS: The analysis of genomic profiles revealed a significantly lower expression of 21 genes with a defined function, involved in immunoglobulin production, lymphocyte function, or regulation of DNA processing in ALL patients referred for HSCT compared with the control group. CONCLUSION: Genome expression of patients with ALL in remission referred to HSCT revealed deep immunosuppression of both B-cell and T-cell lineages, which may increase the probability of donor cell engraftment. SAGE Publications 2022-04-26 /pmc/articles/PMC9052811/ /pubmed/35470705 http://dx.doi.org/10.1177/10732748211064776 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Kwiecinska, Kinga
Strojny, Wojciech
Bik-Multanowski, Miroslaw
Michal Korostynski,
Piechota, Marcin
Balwierz, Walentyna
Szymon Skoczen,
Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation
title Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation
title_full Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation
title_fullStr Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation
title_full_unstemmed Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation
title_short Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation
title_sort genetic profiling in children with acute lymphoblastic leukemia referred for allogeneic hematopoietic stem cell transplantation
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052811/
https://www.ncbi.nlm.nih.gov/pubmed/35470705
http://dx.doi.org/10.1177/10732748211064776
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