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Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation
INTRODUCTION: Hematopoietic stem cell transplantation (HSCT) is the essential and often the only curative therapeutic option in high risk and relapsed pediatric acute lymphoblastic leukemia (ALL). METHODS: The objective of the study was to investigate whole-genome expression in children with high ri...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052811/ https://www.ncbi.nlm.nih.gov/pubmed/35470705 http://dx.doi.org/10.1177/10732748211064776 |
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author | Kwiecinska, Kinga Strojny, Wojciech Bik-Multanowski, Miroslaw Michal Korostynski, Piechota, Marcin Balwierz, Walentyna Szymon Skoczen, |
author_facet | Kwiecinska, Kinga Strojny, Wojciech Bik-Multanowski, Miroslaw Michal Korostynski, Piechota, Marcin Balwierz, Walentyna Szymon Skoczen, |
author_sort | Kwiecinska, Kinga |
collection | PubMed |
description | INTRODUCTION: Hematopoietic stem cell transplantation (HSCT) is the essential and often the only curative therapeutic option in high risk and relapsed pediatric acute lymphoblastic leukemia (ALL). METHODS: The objective of the study was to investigate whole-genome expression in children with high risk or relapsed ALL referred for HSCT. Gene expression was assessed in 18 children with ALL referred for HSCT (10 high risk, 8 relapsed; median age of 9.4 years) and in a control group of 38 obese children (median age of 14.1 years). Whole-genome expression was assessed in leukocytes using GeneChip® HumanGene 1.0 ST microarray. RESULTS: The analysis of genomic profiles revealed a significantly lower expression of 21 genes with a defined function, involved in immunoglobulin production, lymphocyte function, or regulation of DNA processing in ALL patients referred for HSCT compared with the control group. CONCLUSION: Genome expression of patients with ALL in remission referred to HSCT revealed deep immunosuppression of both B-cell and T-cell lineages, which may increase the probability of donor cell engraftment. |
format | Online Article Text |
id | pubmed-9052811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-90528112022-04-30 Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation Kwiecinska, Kinga Strojny, Wojciech Bik-Multanowski, Miroslaw Michal Korostynski, Piechota, Marcin Balwierz, Walentyna Szymon Skoczen, Cancer Control Original Research Article INTRODUCTION: Hematopoietic stem cell transplantation (HSCT) is the essential and often the only curative therapeutic option in high risk and relapsed pediatric acute lymphoblastic leukemia (ALL). METHODS: The objective of the study was to investigate whole-genome expression in children with high risk or relapsed ALL referred for HSCT. Gene expression was assessed in 18 children with ALL referred for HSCT (10 high risk, 8 relapsed; median age of 9.4 years) and in a control group of 38 obese children (median age of 14.1 years). Whole-genome expression was assessed in leukocytes using GeneChip® HumanGene 1.0 ST microarray. RESULTS: The analysis of genomic profiles revealed a significantly lower expression of 21 genes with a defined function, involved in immunoglobulin production, lymphocyte function, or regulation of DNA processing in ALL patients referred for HSCT compared with the control group. CONCLUSION: Genome expression of patients with ALL in remission referred to HSCT revealed deep immunosuppression of both B-cell and T-cell lineages, which may increase the probability of donor cell engraftment. SAGE Publications 2022-04-26 /pmc/articles/PMC9052811/ /pubmed/35470705 http://dx.doi.org/10.1177/10732748211064776 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Kwiecinska, Kinga Strojny, Wojciech Bik-Multanowski, Miroslaw Michal Korostynski, Piechota, Marcin Balwierz, Walentyna Szymon Skoczen, Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation |
title | Genetic Profiling in Children With Acute Lymphoblastic Leukemia
Referred for Allogeneic Hematopoietic Stem Cell Transplantation |
title_full | Genetic Profiling in Children With Acute Lymphoblastic Leukemia
Referred for Allogeneic Hematopoietic Stem Cell Transplantation |
title_fullStr | Genetic Profiling in Children With Acute Lymphoblastic Leukemia
Referred for Allogeneic Hematopoietic Stem Cell Transplantation |
title_full_unstemmed | Genetic Profiling in Children With Acute Lymphoblastic Leukemia
Referred for Allogeneic Hematopoietic Stem Cell Transplantation |
title_short | Genetic Profiling in Children With Acute Lymphoblastic Leukemia
Referred for Allogeneic Hematopoietic Stem Cell Transplantation |
title_sort | genetic profiling in children with acute lymphoblastic leukemia
referred for allogeneic hematopoietic stem cell transplantation |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052811/ https://www.ncbi.nlm.nih.gov/pubmed/35470705 http://dx.doi.org/10.1177/10732748211064776 |
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