Germline GATA2 variant disrupting endothelial eNOS function and angiogenesis can be restored by c-Jun/AP-1 upregulation

GATA2 is a transcription factor with key roles in hematopoiesis. Germline GATA2 gene variants have been associated with several inherited and acquired hematologic disorders, including myelodysplastic syndromes. Among the spectrum of GATA2 deficiency- associated manifestations thrombosis has been rep...

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Detalles Bibliográficos
Autores principales: Purgatorio, Giulio, Piselli, Elisa, Guglielmini, Giuseppe, Falcinelli, Emanuela, Bury, Loredana, Di Battista, Valeria, Pellanera, Fabrizia, Milano, Francesca, Matteucci, Caterina, Mecucci, Cristina, Gresele, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052902/
https://www.ncbi.nlm.nih.gov/pubmed/34233447
http://dx.doi.org/10.3324/haematol.2021.278450

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