A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction

A synthesis of aryloxy phosphoramidate prodrug of alcohols enabled by a transesterification strategy is described here. This reaction operates under mild conditions and thus has excellent functional group tolerance. This method provides an efficient and practical solution to the rapid construction o...

Descripción completa

Detalles Bibliográficos
Autores principales: Ying, Hanglu, Yao, Jie, Wu, Fan, Zhao, Yufen, Ni, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052952/
https://www.ncbi.nlm.nih.gov/pubmed/35497010
http://dx.doi.org/10.1039/d2ra01995g
_version_ 1784696892741910528
author Ying, Hanglu
Yao, Jie
Wu, Fan
Zhao, Yufen
Ni, Feng
author_facet Ying, Hanglu
Yao, Jie
Wu, Fan
Zhao, Yufen
Ni, Feng
author_sort Ying, Hanglu
collection PubMed
description A synthesis of aryloxy phosphoramidate prodrug of alcohols enabled by a transesterification strategy is described here. This reaction operates under mild conditions and thus has excellent functional group tolerance. This method provides an efficient and practical solution to the rapid construction of the aryloxy phosphoramidate prodrugs library for potential SAR studies.
format Online
Article
Text
id pubmed-9052952
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90529522022-04-29 A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction Ying, Hanglu Yao, Jie Wu, Fan Zhao, Yufen Ni, Feng RSC Adv Chemistry A synthesis of aryloxy phosphoramidate prodrug of alcohols enabled by a transesterification strategy is described here. This reaction operates under mild conditions and thus has excellent functional group tolerance. This method provides an efficient and practical solution to the rapid construction of the aryloxy phosphoramidate prodrugs library for potential SAR studies. The Royal Society of Chemistry 2022-04-29 /pmc/articles/PMC9052952/ /pubmed/35497010 http://dx.doi.org/10.1039/d2ra01995g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Ying, Hanglu
Yao, Jie
Wu, Fan
Zhao, Yufen
Ni, Feng
A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction
title A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction
title_full A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction
title_fullStr A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction
title_full_unstemmed A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction
title_short A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction
title_sort mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052952/
https://www.ncbi.nlm.nih.gov/pubmed/35497010
http://dx.doi.org/10.1039/d2ra01995g
work_keys_str_mv AT yinghanglu amildandconcisesynthesisofaryloxyphosphoramidateprodrugofalcoholsviatransesterificationreaction
AT yaojie amildandconcisesynthesisofaryloxyphosphoramidateprodrugofalcoholsviatransesterificationreaction
AT wufan amildandconcisesynthesisofaryloxyphosphoramidateprodrugofalcoholsviatransesterificationreaction
AT zhaoyufen amildandconcisesynthesisofaryloxyphosphoramidateprodrugofalcoholsviatransesterificationreaction
AT nifeng amildandconcisesynthesisofaryloxyphosphoramidateprodrugofalcoholsviatransesterificationreaction
AT yinghanglu mildandconcisesynthesisofaryloxyphosphoramidateprodrugofalcoholsviatransesterificationreaction
AT yaojie mildandconcisesynthesisofaryloxyphosphoramidateprodrugofalcoholsviatransesterificationreaction
AT wufan mildandconcisesynthesisofaryloxyphosphoramidateprodrugofalcoholsviatransesterificationreaction
AT zhaoyufen mildandconcisesynthesisofaryloxyphosphoramidateprodrugofalcoholsviatransesterificationreaction
AT nifeng mildandconcisesynthesisofaryloxyphosphoramidateprodrugofalcoholsviatransesterificationreaction

Ejemplares similares