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Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival
Hepatoma‐derived growth factor (HDGF) was previously shown to be associated with increased mortality in a small study of idiopathic and connective tissue disease‐associated pulmonary arterial hypertension (PAH). In this study, we measured serum HDGF levels in a large multicenter cohort (total 2017 a...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052972/ https://www.ncbi.nlm.nih.gov/pubmed/35506100 http://dx.doi.org/10.1002/pul2.12007 |
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author | Yang, Jun Ambade, Anjira S. Nies, Melanie Griffiths, Megan Damico, Rachel Vaidya, Dhananjay Brandal, Stephanie Pauciulo, Michael W. Lutz, Katie A. Coleman, Anna W. Nichols, William C. Austin, Eric D. Ivy, Dunbar Hassoun, Paul M. Everett, Allen D. |
author_facet | Yang, Jun Ambade, Anjira S. Nies, Melanie Griffiths, Megan Damico, Rachel Vaidya, Dhananjay Brandal, Stephanie Pauciulo, Michael W. Lutz, Katie A. Coleman, Anna W. Nichols, William C. Austin, Eric D. Ivy, Dunbar Hassoun, Paul M. Everett, Allen D. |
author_sort | Yang, Jun |
collection | PubMed |
description | Hepatoma‐derived growth factor (HDGF) was previously shown to be associated with increased mortality in a small study of idiopathic and connective tissue disease‐associated pulmonary arterial hypertension (PAH). In this study, we measured serum HDGF levels in a large multicenter cohort (total 2017 adult PAH‐Biobank enrollees), we analyzed the associations between HDGF levels and various clinical measures using linear or logistic regression models. Higher HDGF levels were found to be significantly associated with worse pulmonary hemodynamics, prostacyclin treatment; among PAH subtypes, higher HDGF levels were most associated with portopulmonary hypertension (beta = 0.469, p < 0.0001). Both Kaplan–Meier curve and Cox proportional hazard regression demonstrated that higher HDGF levels are associated with a higher risk of mortality (COX hazard ratio 1.31, p < 0.0001). Further, in the Sugen hypoxia (SuHx) rat model, the highest HDGF levels were post‐pulmonary circulation, and HDGF levels significantly increased with the development of PAH. In pulmonary arteries, immunohistochemistry staining showed that HDGF was highly expressed in pulmonary smooth muscle cells in both PAH patients and SuHx rats. In conclusion, we found that higher serum HDGF was linked with increased mortality, and associated with disease severity in a large multi‐center adult PAH cohort (n = 2017). In the SuHX PAH models, circulating HDGF levels are pulmonary in origin and increase with PAH progression. HDGF may be actively involved in vascular remodeling in PAH. |
format | Online Article Text |
id | pubmed-9052972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90529722022-05-02 Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival Yang, Jun Ambade, Anjira S. Nies, Melanie Griffiths, Megan Damico, Rachel Vaidya, Dhananjay Brandal, Stephanie Pauciulo, Michael W. Lutz, Katie A. Coleman, Anna W. Nichols, William C. Austin, Eric D. Ivy, Dunbar Hassoun, Paul M. Everett, Allen D. Pulm Circ Research Articles Hepatoma‐derived growth factor (HDGF) was previously shown to be associated with increased mortality in a small study of idiopathic and connective tissue disease‐associated pulmonary arterial hypertension (PAH). In this study, we measured serum HDGF levels in a large multicenter cohort (total 2017 adult PAH‐Biobank enrollees), we analyzed the associations between HDGF levels and various clinical measures using linear or logistic regression models. Higher HDGF levels were found to be significantly associated with worse pulmonary hemodynamics, prostacyclin treatment; among PAH subtypes, higher HDGF levels were most associated with portopulmonary hypertension (beta = 0.469, p < 0.0001). Both Kaplan–Meier curve and Cox proportional hazard regression demonstrated that higher HDGF levels are associated with a higher risk of mortality (COX hazard ratio 1.31, p < 0.0001). Further, in the Sugen hypoxia (SuHx) rat model, the highest HDGF levels were post‐pulmonary circulation, and HDGF levels significantly increased with the development of PAH. In pulmonary arteries, immunohistochemistry staining showed that HDGF was highly expressed in pulmonary smooth muscle cells in both PAH patients and SuHx rats. In conclusion, we found that higher serum HDGF was linked with increased mortality, and associated with disease severity in a large multi‐center adult PAH cohort (n = 2017). In the SuHX PAH models, circulating HDGF levels are pulmonary in origin and increase with PAH progression. HDGF may be actively involved in vascular remodeling in PAH. John Wiley and Sons Inc. 2022-03-07 /pmc/articles/PMC9052972/ /pubmed/35506100 http://dx.doi.org/10.1002/pul2.12007 Text en © 2021 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Yang, Jun Ambade, Anjira S. Nies, Melanie Griffiths, Megan Damico, Rachel Vaidya, Dhananjay Brandal, Stephanie Pauciulo, Michael W. Lutz, Katie A. Coleman, Anna W. Nichols, William C. Austin, Eric D. Ivy, Dunbar Hassoun, Paul M. Everett, Allen D. Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival |
title | Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival |
title_full | Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival |
title_fullStr | Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival |
title_full_unstemmed | Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival |
title_short | Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival |
title_sort | hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and pah disease severity and survival |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052972/ https://www.ncbi.nlm.nih.gov/pubmed/35506100 http://dx.doi.org/10.1002/pul2.12007 |
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