Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension

BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hyper...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Bin, Yi, Dan, Pan, Jiakai, Dai, Jingbo, Zhu, Maggie M., Zhao, You‐Yang, Oh, S. Paul, Fallon, Michael B., Dai, Zhiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052986/
https://www.ncbi.nlm.nih.gov/pubmed/35506101
http://dx.doi.org/10.1002/pul2.12056
Descripción
Sumario:BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.

Ejemplares similares