Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension

BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hyper...

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Detalles Bibliográficos
Autores principales: Liu, Bin, Yi, Dan, Pan, Jiakai, Dai, Jingbo, Zhu, Maggie M., Zhao, You‐Yang, Oh, S. Paul, Fallon, Michael B., Dai, Zhiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052986/
https://www.ncbi.nlm.nih.gov/pubmed/35506101
http://dx.doi.org/10.1002/pul2.12056
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author Liu, Bin
Yi, Dan
Pan, Jiakai
Dai, Jingbo
Zhu, Maggie M.
Zhao, You‐Yang
Oh, S. Paul
Fallon, Michael B.
Dai, Zhiyu
author_facet Liu, Bin
Yi, Dan
Pan, Jiakai
Dai, Jingbo
Zhu, Maggie M.
Zhao, You‐Yang
Oh, S. Paul
Fallon, Michael B.
Dai, Zhiyu
author_sort Liu, Bin
collection PubMed
description BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.
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spelling pubmed-90529862022-05-02 Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension Liu, Bin Yi, Dan Pan, Jiakai Dai, Jingbo Zhu, Maggie M. Zhao, You‐Yang Oh, S. Paul Fallon, Michael B. Dai, Zhiyu Pulm Circ Research Letter BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension. John Wiley and Sons Inc. 2022-03-23 /pmc/articles/PMC9052986/ /pubmed/35506101 http://dx.doi.org/10.1002/pul2.12056 Text en © 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Letter
Liu, Bin
Yi, Dan
Pan, Jiakai
Dai, Jingbo
Zhu, Maggie M.
Zhao, You‐Yang
Oh, S. Paul
Fallon, Michael B.
Dai, Zhiyu
Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension
title Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension
title_full Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension
title_fullStr Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension
title_full_unstemmed Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension
title_short Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension
title_sort suppression of bmp signaling by phd2 deficiency in pulmonary arterial hypertension
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052986/
https://www.ncbi.nlm.nih.gov/pubmed/35506101
http://dx.doi.org/10.1002/pul2.12056
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