Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension

Recent evidence suggests pulmonary hypertension (PH), a disease of the pulmonary vasculature actually has multiorgan pathophysiology and perhaps etiology. Herein, we demonstrated that fecal matter transplantation from angiotensin‐converting enzyme 2 overexpressing mice counteracted the effects of ch...

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Autores principales: Oliveira, Aline C., Yang, Tao, Li, Jing, Sharma, Ravindra K., Karas, Marianthi K., Bryant, Andrew J., de Kloet, Annette D., Krause, Eric G., Joe, Bina, Richards, Elaine M., Raizada, Mohan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052990/
https://www.ncbi.nlm.nih.gov/pubmed/35506083
http://dx.doi.org/10.1002/pul2.12015
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author Oliveira, Aline C.
Yang, Tao
Li, Jing
Sharma, Ravindra K.
Karas, Marianthi K.
Bryant, Andrew J.
de Kloet, Annette D.
Krause, Eric G.
Joe, Bina
Richards, Elaine M.
Raizada, Mohan K.
author_facet Oliveira, Aline C.
Yang, Tao
Li, Jing
Sharma, Ravindra K.
Karas, Marianthi K.
Bryant, Andrew J.
de Kloet, Annette D.
Krause, Eric G.
Joe, Bina
Richards, Elaine M.
Raizada, Mohan K.
author_sort Oliveira, Aline C.
collection PubMed
description Recent evidence suggests pulmonary hypertension (PH), a disease of the pulmonary vasculature actually has multiorgan pathophysiology and perhaps etiology. Herein, we demonstrated that fecal matter transplantation from angiotensin‐converting enzyme 2 overexpressing mice counteracted the effects of chronic hypoxia to prevent pulmonary hypertension, neuroinflammation, and gut dysbiosis in wild type recipients.
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spelling pubmed-90529902022-05-02 Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension Oliveira, Aline C. Yang, Tao Li, Jing Sharma, Ravindra K. Karas, Marianthi K. Bryant, Andrew J. de Kloet, Annette D. Krause, Eric G. Joe, Bina Richards, Elaine M. Raizada, Mohan K. Pulm Circ Research Letter Recent evidence suggests pulmonary hypertension (PH), a disease of the pulmonary vasculature actually has multiorgan pathophysiology and perhaps etiology. Herein, we demonstrated that fecal matter transplantation from angiotensin‐converting enzyme 2 overexpressing mice counteracted the effects of chronic hypoxia to prevent pulmonary hypertension, neuroinflammation, and gut dysbiosis in wild type recipients. John Wiley and Sons Inc. 2022-01-10 /pmc/articles/PMC9052990/ /pubmed/35506083 http://dx.doi.org/10.1002/pul2.12015 Text en © 2021 The Authors. Pulmonary Circulation published by Wiley Periodicals LLC on behalf of the Pulmonary Vascular Research Institute. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of thehttp://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Letter
Oliveira, Aline C.
Yang, Tao
Li, Jing
Sharma, Ravindra K.
Karas, Marianthi K.
Bryant, Andrew J.
de Kloet, Annette D.
Krause, Eric G.
Joe, Bina
Richards, Elaine M.
Raizada, Mohan K.
Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension
title Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension
title_full Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension
title_fullStr Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension
title_full_unstemmed Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension
title_short Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension
title_sort fecal matter transplant from ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052990/
https://www.ncbi.nlm.nih.gov/pubmed/35506083
http://dx.doi.org/10.1002/pul2.12015
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