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Inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: Report of five cases

Inflammatory pseudotumor (IPT), also known as plasma cell granuloma, is a rare lesion of unknown etiology that occurs in many organs, especially in the lung. Here we report five cases of IPT arising in pulmonary artery mimicking chronic thromboembolic disease, not previously documented in the litera...

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Autores principales: Liao, Xiaoyan, Bojanowski, Christine M., Yen, Andrew, Kerr, Kim M., Dumouchel, Justin, Auger, William R., Madani, Michael M., Pretorius, Victor, Wang, Huan‐You, Yi, Eunhee S., Lin, Grace Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053012/
https://www.ncbi.nlm.nih.gov/pubmed/35506111
http://dx.doi.org/10.1002/pul2.12004
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author Liao, Xiaoyan
Bojanowski, Christine M.
Yen, Andrew
Kerr, Kim M.
Dumouchel, Justin
Auger, William R.
Madani, Michael M.
Pretorius, Victor
Wang, Huan‐You
Yi, Eunhee S.
Lin, Grace Y.
author_facet Liao, Xiaoyan
Bojanowski, Christine M.
Yen, Andrew
Kerr, Kim M.
Dumouchel, Justin
Auger, William R.
Madani, Michael M.
Pretorius, Victor
Wang, Huan‐You
Yi, Eunhee S.
Lin, Grace Y.
author_sort Liao, Xiaoyan
collection PubMed
description Inflammatory pseudotumor (IPT), also known as plasma cell granuloma, is a rare lesion of unknown etiology that occurs in many organs, especially in the lung. Here we report five cases of IPT arising in pulmonary artery mimicking chronic thromboembolic disease, not previously documented in the literature. Those cases were identified at our institute among over 2500 pulmonary endarterectomy (PEA) specimens acquired from 2000 to 2017. The cohort included three men and two women with a median age of 41 years (range: 23–54). All patients presented with dyspnea and radiologic findings of pulmonary artery thromboembolism, some concerning for intimal sarcoma. The duration between disease onset and PEA ranged from 6 months to approximately 3 years. Histologically, all cases showed proliferation of spindle cells with marked inflammatory infiltrates composed predominantly of plasma cells, histiocytes, and small lymphocytes. Ancillary studies were performed in each case and ruled out other possibilities, such as sarcoma, lymphoma, plasmacytoma, IgG4‐related disease, and infection. IPT arising in pulmonary artery presenting clinically as acute or chronic thromboembolic disease is very unusual, in which clinical data, radiographic findings, and histopathologic features have to be integrated for reaching the proper diagnosis.
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spelling pubmed-90530122022-05-02 Inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: Report of five cases Liao, Xiaoyan Bojanowski, Christine M. Yen, Andrew Kerr, Kim M. Dumouchel, Justin Auger, William R. Madani, Michael M. Pretorius, Victor Wang, Huan‐You Yi, Eunhee S. Lin, Grace Y. Pulm Circ Case Reports Inflammatory pseudotumor (IPT), also known as plasma cell granuloma, is a rare lesion of unknown etiology that occurs in many organs, especially in the lung. Here we report five cases of IPT arising in pulmonary artery mimicking chronic thromboembolic disease, not previously documented in the literature. Those cases were identified at our institute among over 2500 pulmonary endarterectomy (PEA) specimens acquired from 2000 to 2017. The cohort included three men and two women with a median age of 41 years (range: 23–54). All patients presented with dyspnea and radiologic findings of pulmonary artery thromboembolism, some concerning for intimal sarcoma. The duration between disease onset and PEA ranged from 6 months to approximately 3 years. Histologically, all cases showed proliferation of spindle cells with marked inflammatory infiltrates composed predominantly of plasma cells, histiocytes, and small lymphocytes. Ancillary studies were performed in each case and ruled out other possibilities, such as sarcoma, lymphoma, plasmacytoma, IgG4‐related disease, and infection. IPT arising in pulmonary artery presenting clinically as acute or chronic thromboembolic disease is very unusual, in which clinical data, radiographic findings, and histopathologic features have to be integrated for reaching the proper diagnosis. John Wiley and Sons Inc. 2021-12-29 /pmc/articles/PMC9053012/ /pubmed/35506111 http://dx.doi.org/10.1002/pul2.12004 Text en © 2021 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Liao, Xiaoyan
Bojanowski, Christine M.
Yen, Andrew
Kerr, Kim M.
Dumouchel, Justin
Auger, William R.
Madani, Michael M.
Pretorius, Victor
Wang, Huan‐You
Yi, Eunhee S.
Lin, Grace Y.
Inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: Report of five cases
title Inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: Report of five cases
title_full Inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: Report of five cases
title_fullStr Inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: Report of five cases
title_full_unstemmed Inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: Report of five cases
title_short Inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: Report of five cases
title_sort inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: report of five cases
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053012/
https://www.ncbi.nlm.nih.gov/pubmed/35506111
http://dx.doi.org/10.1002/pul2.12004
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