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Differences in learning and memory between middle-aged female and male rats
We observed differences in cognitive functions between middle-aged female and male Wistar rats. Both (like youngsters) discriminated new versus familiar objects, showing similar short- and long-term memory (STM and LTM, respectively). Only females show robust LTM for new location of an object. Both...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053109/ https://www.ncbi.nlm.nih.gov/pubmed/35428728 http://dx.doi.org/10.1101/lm.053578.122 |
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author | Colettis, Natalia Claudia Habif, Martín Oberholzer, María Victoria Filippin, Federico Jerusalinsky, Diana Alicia |
author_facet | Colettis, Natalia Claudia Habif, Martín Oberholzer, María Victoria Filippin, Federico Jerusalinsky, Diana Alicia |
author_sort | Colettis, Natalia Claudia |
collection | PubMed |
description | We observed differences in cognitive functions between middle-aged female and male Wistar rats. Both (like youngsters) discriminated new versus familiar objects, showing similar short- and long-term memory (STM and LTM, respectively). Only females show robust LTM for new location of an object. Both successfully form LTM of inhibitory avoidance, though males appeared to be amnesic for memory persistence. Habituation, locomotion, horizontal exploration, “stereotypies,” fear, and anxiety-like behavior were similar for both, while vertical exploration was significantly higher in middle-aged and younger females. Therefore, sex-dependent differences in some cognitive functions and behaviors must be considered when designing and interpreting learning and memory studies. |
format | Online Article Text |
id | pubmed-9053109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-90531092023-05-01 Differences in learning and memory between middle-aged female and male rats Colettis, Natalia Claudia Habif, Martín Oberholzer, María Victoria Filippin, Federico Jerusalinsky, Diana Alicia Learn Mem Brief Communication We observed differences in cognitive functions between middle-aged female and male Wistar rats. Both (like youngsters) discriminated new versus familiar objects, showing similar short- and long-term memory (STM and LTM, respectively). Only females show robust LTM for new location of an object. Both successfully form LTM of inhibitory avoidance, though males appeared to be amnesic for memory persistence. Habituation, locomotion, horizontal exploration, “stereotypies,” fear, and anxiety-like behavior were similar for both, while vertical exploration was significantly higher in middle-aged and younger females. Therefore, sex-dependent differences in some cognitive functions and behaviors must be considered when designing and interpreting learning and memory studies. Cold Spring Harbor Laboratory Press 2022-05 /pmc/articles/PMC9053109/ /pubmed/35428728 http://dx.doi.org/10.1101/lm.053578.122 Text en © 2022 Colettis et al.; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by-nc/4.0/This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Brief Communication Colettis, Natalia Claudia Habif, Martín Oberholzer, María Victoria Filippin, Federico Jerusalinsky, Diana Alicia Differences in learning and memory between middle-aged female and male rats |
title | Differences in learning and memory between middle-aged female and male rats |
title_full | Differences in learning and memory between middle-aged female and male rats |
title_fullStr | Differences in learning and memory between middle-aged female and male rats |
title_full_unstemmed | Differences in learning and memory between middle-aged female and male rats |
title_short | Differences in learning and memory between middle-aged female and male rats |
title_sort | differences in learning and memory between middle-aged female and male rats |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053109/ https://www.ncbi.nlm.nih.gov/pubmed/35428728 http://dx.doi.org/10.1101/lm.053578.122 |
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