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Differences in learning and memory between middle-aged female and male rats

We observed differences in cognitive functions between middle-aged female and male Wistar rats. Both (like youngsters) discriminated new versus familiar objects, showing similar short- and long-term memory (STM and LTM, respectively). Only females show robust LTM for new location of an object. Both...

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Autores principales: Colettis, Natalia Claudia, Habif, Martín, Oberholzer, María Victoria, Filippin, Federico, Jerusalinsky, Diana Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053109/
https://www.ncbi.nlm.nih.gov/pubmed/35428728
http://dx.doi.org/10.1101/lm.053578.122
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author Colettis, Natalia Claudia
Habif, Martín
Oberholzer, María Victoria
Filippin, Federico
Jerusalinsky, Diana Alicia
author_facet Colettis, Natalia Claudia
Habif, Martín
Oberholzer, María Victoria
Filippin, Federico
Jerusalinsky, Diana Alicia
author_sort Colettis, Natalia Claudia
collection PubMed
description We observed differences in cognitive functions between middle-aged female and male Wistar rats. Both (like youngsters) discriminated new versus familiar objects, showing similar short- and long-term memory (STM and LTM, respectively). Only females show robust LTM for new location of an object. Both successfully form LTM of inhibitory avoidance, though males appeared to be amnesic for memory persistence. Habituation, locomotion, horizontal exploration, “stereotypies,” fear, and anxiety-like behavior were similar for both, while vertical exploration was significantly higher in middle-aged and younger females. Therefore, sex-dependent differences in some cognitive functions and behaviors must be considered when designing and interpreting learning and memory studies.
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spelling pubmed-90531092023-05-01 Differences in learning and memory between middle-aged female and male rats Colettis, Natalia Claudia Habif, Martín Oberholzer, María Victoria Filippin, Federico Jerusalinsky, Diana Alicia Learn Mem Brief Communication We observed differences in cognitive functions between middle-aged female and male Wistar rats. Both (like youngsters) discriminated new versus familiar objects, showing similar short- and long-term memory (STM and LTM, respectively). Only females show robust LTM for new location of an object. Both successfully form LTM of inhibitory avoidance, though males appeared to be amnesic for memory persistence. Habituation, locomotion, horizontal exploration, “stereotypies,” fear, and anxiety-like behavior were similar for both, while vertical exploration was significantly higher in middle-aged and younger females. Therefore, sex-dependent differences in some cognitive functions and behaviors must be considered when designing and interpreting learning and memory studies. Cold Spring Harbor Laboratory Press 2022-05 /pmc/articles/PMC9053109/ /pubmed/35428728 http://dx.doi.org/10.1101/lm.053578.122 Text en © 2022 Colettis et al.; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by-nc/4.0/This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Brief Communication
Colettis, Natalia Claudia
Habif, Martín
Oberholzer, María Victoria
Filippin, Federico
Jerusalinsky, Diana Alicia
Differences in learning and memory between middle-aged female and male rats
title Differences in learning and memory between middle-aged female and male rats
title_full Differences in learning and memory between middle-aged female and male rats
title_fullStr Differences in learning and memory between middle-aged female and male rats
title_full_unstemmed Differences in learning and memory between middle-aged female and male rats
title_short Differences in learning and memory between middle-aged female and male rats
title_sort differences in learning and memory between middle-aged female and male rats
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053109/
https://www.ncbi.nlm.nih.gov/pubmed/35428728
http://dx.doi.org/10.1101/lm.053578.122
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