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SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal
BACKGROUND: Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. METHODS: By applying recent phylodynamic models that allow inte...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053228/ https://www.ncbi.nlm.nih.gov/pubmed/35603268 http://dx.doi.org/10.1038/s43856-022-00072-0 |
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author | Borges, Vítor Isidro, Joana Trovão, Nídia Sequeira Duarte, Sílvia Cortes-Martins, Helena Martiniano, Hugo Gordo, Isabel Leite, Ricardo Vieira, Luís Guiomar, Raquel Gomes, João Paulo |
author_facet | Borges, Vítor Isidro, Joana Trovão, Nídia Sequeira Duarte, Sílvia Cortes-Martins, Helena Martiniano, Hugo Gordo, Isabel Leite, Ricardo Vieira, Luís Guiomar, Raquel Gomes, João Paulo |
author_sort | Borges, Vítor |
collection | PubMed |
description | BACKGROUND: Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. METHODS: By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARS-CoV-2 introductions and early dissemination in Portugal. RESULTS: We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. CONCLUSIONS: Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance. |
format | Online Article Text |
id | pubmed-9053228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90532282022-05-20 SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal Borges, Vítor Isidro, Joana Trovão, Nídia Sequeira Duarte, Sílvia Cortes-Martins, Helena Martiniano, Hugo Gordo, Isabel Leite, Ricardo Vieira, Luís Guiomar, Raquel Gomes, João Paulo Commun Med (Lond) Article BACKGROUND: Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. METHODS: By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARS-CoV-2 introductions and early dissemination in Portugal. RESULTS: We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. CONCLUSIONS: Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance. Nature Publishing Group UK 2022-01-28 /pmc/articles/PMC9053228/ /pubmed/35603268 http://dx.doi.org/10.1038/s43856-022-00072-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Borges, Vítor Isidro, Joana Trovão, Nídia Sequeira Duarte, Sílvia Cortes-Martins, Helena Martiniano, Hugo Gordo, Isabel Leite, Ricardo Vieira, Luís Guiomar, Raquel Gomes, João Paulo SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal |
title | SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal |
title_full | SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal |
title_fullStr | SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal |
title_full_unstemmed | SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal |
title_short | SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal |
title_sort | sars-cov-2 introductions and early dynamics of the epidemic in portugal |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053228/ https://www.ncbi.nlm.nih.gov/pubmed/35603268 http://dx.doi.org/10.1038/s43856-022-00072-0 |
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