Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste

(S)-5-Methyl-tetrahydropyran-2-one 1 is a by-product in the production of key intermediates of steroidal hormones. Asymmetric synthesis of natural oxacyclododecindione-type macrolactones 2 and 3 has been realized for the first time from (S)-1 in seven and eight steps with 37% and 27% overall yield,...

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Detalles Bibliográficos
Autores principales: Liu, Xian, Nie, Huifang, Yao, Lin, Jiang, Ru, Chen, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053229/
https://www.ncbi.nlm.nih.gov/pubmed/35496927
http://dx.doi.org/10.1039/d0ra02994g
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author Liu, Xian
Nie, Huifang
Yao, Lin
Jiang, Ru
Chen, Weiping
author_facet Liu, Xian
Nie, Huifang
Yao, Lin
Jiang, Ru
Chen, Weiping
author_sort Liu, Xian
collection PubMed
description (S)-5-Methyl-tetrahydropyran-2-one 1 is a by-product in the production of key intermediates of steroidal hormones. Asymmetric synthesis of natural oxacyclododecindione-type macrolactones 2 and 3 has been realized for the first time from (S)-1 in seven and eight steps with 37% and 27% overall yield, respectively.
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spelling pubmed-90532292022-04-29 Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste Liu, Xian Nie, Huifang Yao, Lin Jiang, Ru Chen, Weiping RSC Adv Chemistry (S)-5-Methyl-tetrahydropyran-2-one 1 is a by-product in the production of key intermediates of steroidal hormones. Asymmetric synthesis of natural oxacyclododecindione-type macrolactones 2 and 3 has been realized for the first time from (S)-1 in seven and eight steps with 37% and 27% overall yield, respectively. The Royal Society of Chemistry 2020-04-30 /pmc/articles/PMC9053229/ /pubmed/35496927 http://dx.doi.org/10.1039/d0ra02994g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Liu, Xian
Nie, Huifang
Yao, Lin
Jiang, Ru
Chen, Weiping
Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste
title Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste
title_full Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste
title_fullStr Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste
title_full_unstemmed Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste
title_short Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste
title_sort concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053229/
https://www.ncbi.nlm.nih.gov/pubmed/35496927
http://dx.doi.org/10.1039/d0ra02994g
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