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Prior fluid and electrolyte imbalance is associated with COVID-19 mortality
BACKGROUND: The COVID-19 pandemic represents a major public health threat. Risk of death from the infection is associated with age and pre-existing comorbidities such as diabetes, dementia, cancer, and impairment of immunological, hepatic or renal function. It remains incompletely understood why som...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053234/ https://www.ncbi.nlm.nih.gov/pubmed/35602191 http://dx.doi.org/10.1038/s43856-021-00051-x |
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author | Nahkuri, Satu Becker, Tim Schueller, Vitalia Massberg, Steffen Bauer-Mehren, Anna |
author_facet | Nahkuri, Satu Becker, Tim Schueller, Vitalia Massberg, Steffen Bauer-Mehren, Anna |
author_sort | Nahkuri, Satu |
collection | PubMed |
description | BACKGROUND: The COVID-19 pandemic represents a major public health threat. Risk of death from the infection is associated with age and pre-existing comorbidities such as diabetes, dementia, cancer, and impairment of immunological, hepatic or renal function. It remains incompletely understood why some patients survive the disease, while others do not. As such, we sought to identify novel prognostic factors for COVID-19 mortality. METHODS: We performed an unbiased, observational retrospective analysis of real world data. Our multivariable and univariable analyses make use of U.S. electronic health records from 122,250 COVID-19 patients in the early stages of the pandemic. RESULTS: Here we show that a priori diagnoses of fluid, pH and electrolyte imbalance during the year preceding the infection are associated with an increased risk of death independently of age and prior renal comorbidities. CONCLUSIONS: We propose that future interventional studies should investigate whether the risk of death can be alleviated by diligent and personalized management of the fluid and electrolyte balance of at-risk individuals during and before COVID-19. |
format | Online Article Text |
id | pubmed-9053234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90532342022-05-20 Prior fluid and electrolyte imbalance is associated with COVID-19 mortality Nahkuri, Satu Becker, Tim Schueller, Vitalia Massberg, Steffen Bauer-Mehren, Anna Commun Med (Lond) Article BACKGROUND: The COVID-19 pandemic represents a major public health threat. Risk of death from the infection is associated with age and pre-existing comorbidities such as diabetes, dementia, cancer, and impairment of immunological, hepatic or renal function. It remains incompletely understood why some patients survive the disease, while others do not. As such, we sought to identify novel prognostic factors for COVID-19 mortality. METHODS: We performed an unbiased, observational retrospective analysis of real world data. Our multivariable and univariable analyses make use of U.S. electronic health records from 122,250 COVID-19 patients in the early stages of the pandemic. RESULTS: Here we show that a priori diagnoses of fluid, pH and electrolyte imbalance during the year preceding the infection are associated with an increased risk of death independently of age and prior renal comorbidities. CONCLUSIONS: We propose that future interventional studies should investigate whether the risk of death can be alleviated by diligent and personalized management of the fluid and electrolyte balance of at-risk individuals during and before COVID-19. Nature Publishing Group UK 2021-11-25 /pmc/articles/PMC9053234/ /pubmed/35602191 http://dx.doi.org/10.1038/s43856-021-00051-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Nahkuri, Satu Becker, Tim Schueller, Vitalia Massberg, Steffen Bauer-Mehren, Anna Prior fluid and electrolyte imbalance is associated with COVID-19 mortality |
title | Prior fluid and electrolyte imbalance is associated with COVID-19 mortality |
title_full | Prior fluid and electrolyte imbalance is associated with COVID-19 mortality |
title_fullStr | Prior fluid and electrolyte imbalance is associated with COVID-19 mortality |
title_full_unstemmed | Prior fluid and electrolyte imbalance is associated with COVID-19 mortality |
title_short | Prior fluid and electrolyte imbalance is associated with COVID-19 mortality |
title_sort | prior fluid and electrolyte imbalance is associated with covid-19 mortality |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053234/ https://www.ncbi.nlm.nih.gov/pubmed/35602191 http://dx.doi.org/10.1038/s43856-021-00051-x |
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