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A 2-month field cohort study of SARS-CoV-2 in saliva of BNT162b2 vaccinated nursing home workers
BACKGROUND: Nursing home (NH) residents have been severely affected during the COVID-19 pandemic because of their age and underlying comorbidities. Infection and outbreaks in NHs are most likely triggered by infected workers. Screening for asymptomatic NH workers can prevent risky contact and viral...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053279/ https://www.ncbi.nlm.nih.gov/pubmed/35603280 http://dx.doi.org/10.1038/s43856-021-00067-3 |
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author | Saegerman, Claude Diep, Anh Nguyet Renault, Véronique Donneau, Anne-Françoise Stamatakis, Lambert Coppieters, Wouter Michel, Fabienne Breuer, Christophe Dandoy, Margaux Ek, Olivier Gourzones, Claire Schyns, Joey Goffin, Emeline Minner, Frédéric Durkin, Keith Artesi, Maria Bours, Vincent Bureau, Fabrice Gillet, Laurent |
author_facet | Saegerman, Claude Diep, Anh Nguyet Renault, Véronique Donneau, Anne-Françoise Stamatakis, Lambert Coppieters, Wouter Michel, Fabienne Breuer, Christophe Dandoy, Margaux Ek, Olivier Gourzones, Claire Schyns, Joey Goffin, Emeline Minner, Frédéric Durkin, Keith Artesi, Maria Bours, Vincent Bureau, Fabrice Gillet, Laurent |
author_sort | Saegerman, Claude |
collection | PubMed |
description | BACKGROUND: Nursing home (NH) residents have been severely affected during the COVID-19 pandemic because of their age and underlying comorbidities. Infection and outbreaks in NHs are most likely triggered by infected workers. Screening for asymptomatic NH workers can prevent risky contact and viral transmission to the residents. This study examined the effect of the BNT162b2 mRNA COVID‑19 (Comirnaty(®); BioNTech and Pfizer) vaccination on the saliva excretion of SARS-CoV-2 among NH workers, through weekly saliva RT-qPCR testing. METHODS: A 2-month cohort study was conducted among 99 NHs in the Walloon region (Belgium), at the start of February 2021. Three groups of workers, i.e., non-vaccinated (n = 1618), one-dosed vaccinated (n = 1454), and two-dosed vaccinated (n = 2379) of BNT162b2 mRNA COVID‑19 vaccine, were followed-up weekly. Their saliva samples were used to monitor the shedding of SARS-CoV-2. All positive samples were sequenced and genotyped to identify the circulating wild-type virus or variants of concern. RESULTS: The protection fraction against the excretion of the SARS-CoV-2 in the saliva samples of the workers after the second dose is estimated at 0.90 (95% CI: 0.18; 0.99) at 1 week and 0.83 (95% CI: 0.54; 0.95) at 8 weeks. We observe more circulating SARS-CoV-2 and a greater variability of viral loads in the unvaccinated group compared to those of the vaccinated group. CONCLUSIONS: This field cohort study advances our knowledge of the efficacy of the mRNA BNT162b2 COVID-19 vaccine on the viral shedding in the saliva specimens of vaccinated NH workers, contributing to better decision-making in public health interventions and management. |
format | Online Article Text |
id | pubmed-9053279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90532792022-05-20 A 2-month field cohort study of SARS-CoV-2 in saliva of BNT162b2 vaccinated nursing home workers Saegerman, Claude Diep, Anh Nguyet Renault, Véronique Donneau, Anne-Françoise Stamatakis, Lambert Coppieters, Wouter Michel, Fabienne Breuer, Christophe Dandoy, Margaux Ek, Olivier Gourzones, Claire Schyns, Joey Goffin, Emeline Minner, Frédéric Durkin, Keith Artesi, Maria Bours, Vincent Bureau, Fabrice Gillet, Laurent Commun Med (Lond) Article BACKGROUND: Nursing home (NH) residents have been severely affected during the COVID-19 pandemic because of their age and underlying comorbidities. Infection and outbreaks in NHs are most likely triggered by infected workers. Screening for asymptomatic NH workers can prevent risky contact and viral transmission to the residents. This study examined the effect of the BNT162b2 mRNA COVID‑19 (Comirnaty(®); BioNTech and Pfizer) vaccination on the saliva excretion of SARS-CoV-2 among NH workers, through weekly saliva RT-qPCR testing. METHODS: A 2-month cohort study was conducted among 99 NHs in the Walloon region (Belgium), at the start of February 2021. Three groups of workers, i.e., non-vaccinated (n = 1618), one-dosed vaccinated (n = 1454), and two-dosed vaccinated (n = 2379) of BNT162b2 mRNA COVID‑19 vaccine, were followed-up weekly. Their saliva samples were used to monitor the shedding of SARS-CoV-2. All positive samples were sequenced and genotyped to identify the circulating wild-type virus or variants of concern. RESULTS: The protection fraction against the excretion of the SARS-CoV-2 in the saliva samples of the workers after the second dose is estimated at 0.90 (95% CI: 0.18; 0.99) at 1 week and 0.83 (95% CI: 0.54; 0.95) at 8 weeks. We observe more circulating SARS-CoV-2 and a greater variability of viral loads in the unvaccinated group compared to those of the vaccinated group. CONCLUSIONS: This field cohort study advances our knowledge of the efficacy of the mRNA BNT162b2 COVID-19 vaccine on the viral shedding in the saliva specimens of vaccinated NH workers, contributing to better decision-making in public health interventions and management. Nature Publishing Group UK 2022-01-10 /pmc/articles/PMC9053279/ /pubmed/35603280 http://dx.doi.org/10.1038/s43856-021-00067-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Saegerman, Claude Diep, Anh Nguyet Renault, Véronique Donneau, Anne-Françoise Stamatakis, Lambert Coppieters, Wouter Michel, Fabienne Breuer, Christophe Dandoy, Margaux Ek, Olivier Gourzones, Claire Schyns, Joey Goffin, Emeline Minner, Frédéric Durkin, Keith Artesi, Maria Bours, Vincent Bureau, Fabrice Gillet, Laurent A 2-month field cohort study of SARS-CoV-2 in saliva of BNT162b2 vaccinated nursing home workers |
title | A 2-month field cohort study of SARS-CoV-2 in saliva of BNT162b2 vaccinated nursing home workers |
title_full | A 2-month field cohort study of SARS-CoV-2 in saliva of BNT162b2 vaccinated nursing home workers |
title_fullStr | A 2-month field cohort study of SARS-CoV-2 in saliva of BNT162b2 vaccinated nursing home workers |
title_full_unstemmed | A 2-month field cohort study of SARS-CoV-2 in saliva of BNT162b2 vaccinated nursing home workers |
title_short | A 2-month field cohort study of SARS-CoV-2 in saliva of BNT162b2 vaccinated nursing home workers |
title_sort | 2-month field cohort study of sars-cov-2 in saliva of bnt162b2 vaccinated nursing home workers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053279/ https://www.ncbi.nlm.nih.gov/pubmed/35603280 http://dx.doi.org/10.1038/s43856-021-00067-3 |
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