Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones

A simple two catalyst component system consisting of primary β-amino alcohols as a catalyst and amino acids as a co-catalyst put together works as an efficient organocatalyst system in the hetero Diels–Alder reaction of isatins with enones to afford the chiral spirooxindole–tetrahydropyranones in go...

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Autores principales: Parasuraman, Perumalsamy, Begum, Zubeda, Chennapuram, Madhu, Seki, Chigusa, Okuyama, Yuko, Kwon, Eunsang, Uwai, Koji, Tokiwa, Michio, Tokiwa, Suguru, Takeshita, Mitsuhiro, Nakano, Hiroto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053445/
https://www.ncbi.nlm.nih.gov/pubmed/35515584
http://dx.doi.org/10.1039/d0ra03006f
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author Parasuraman, Perumalsamy
Begum, Zubeda
Chennapuram, Madhu
Seki, Chigusa
Okuyama, Yuko
Kwon, Eunsang
Uwai, Koji
Tokiwa, Michio
Tokiwa, Suguru
Takeshita, Mitsuhiro
Nakano, Hiroto
author_facet Parasuraman, Perumalsamy
Begum, Zubeda
Chennapuram, Madhu
Seki, Chigusa
Okuyama, Yuko
Kwon, Eunsang
Uwai, Koji
Tokiwa, Michio
Tokiwa, Suguru
Takeshita, Mitsuhiro
Nakano, Hiroto
author_sort Parasuraman, Perumalsamy
collection PubMed
description A simple two catalyst component system consisting of primary β-amino alcohols as a catalyst and amino acids as a co-catalyst put together works as an efficient organocatalyst system in the hetero Diels–Alder reaction of isatins with enones to afford the chiral spirooxindole–tetrahydropyranones in good chemical yields and stereoselectivities (up to 86%, up to 85 : 15 dr., up to 95% ee).
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spelling pubmed-90534452022-05-04 Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones Parasuraman, Perumalsamy Begum, Zubeda Chennapuram, Madhu Seki, Chigusa Okuyama, Yuko Kwon, Eunsang Uwai, Koji Tokiwa, Michio Tokiwa, Suguru Takeshita, Mitsuhiro Nakano, Hiroto RSC Adv Chemistry A simple two catalyst component system consisting of primary β-amino alcohols as a catalyst and amino acids as a co-catalyst put together works as an efficient organocatalyst system in the hetero Diels–Alder reaction of isatins with enones to afford the chiral spirooxindole–tetrahydropyranones in good chemical yields and stereoselectivities (up to 86%, up to 85 : 15 dr., up to 95% ee). The Royal Society of Chemistry 2020-05-05 /pmc/articles/PMC9053445/ /pubmed/35515584 http://dx.doi.org/10.1039/d0ra03006f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Parasuraman, Perumalsamy
Begum, Zubeda
Chennapuram, Madhu
Seki, Chigusa
Okuyama, Yuko
Kwon, Eunsang
Uwai, Koji
Tokiwa, Michio
Tokiwa, Suguru
Takeshita, Mitsuhiro
Nakano, Hiroto
Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones
title Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones
title_full Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones
title_fullStr Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones
title_full_unstemmed Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones
title_short Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones
title_sort simple organocatalyst component system for asymmetric hetero diels–alder reaction of isatins with enones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053445/
https://www.ncbi.nlm.nih.gov/pubmed/35515584
http://dx.doi.org/10.1039/d0ra03006f
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