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Coenzyme Q(10) Reduces Infarct Size in Animal Models of Myocardial Ischemia-Reperfusion Injury: A Meta-Analysis and Summary of Underlying Mechanisms
OBJECTIVE: Effective interventions that might limit myocardial ischemia-reperfusion (I/R) injury are still lacking. Coenzyme Q(10) (CoQ(10)) may exert cardioprotective actions that reduce myocardial I/R injury. We conducted this meta-analysis to assess the potential cardioprotective effect of CoQ(10...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053645/ https://www.ncbi.nlm.nih.gov/pubmed/35498032 http://dx.doi.org/10.3389/fcvm.2022.857364 |
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author | Awad, Kamal Sayed, Ahmed Banach, Maciej |
author_facet | Awad, Kamal Sayed, Ahmed Banach, Maciej |
author_sort | Awad, Kamal |
collection | PubMed |
description | OBJECTIVE: Effective interventions that might limit myocardial ischemia-reperfusion (I/R) injury are still lacking. Coenzyme Q(10) (CoQ(10)) may exert cardioprotective actions that reduce myocardial I/R injury. We conducted this meta-analysis to assess the potential cardioprotective effect of CoQ(10) in animal models of myocardial I/R injury. METHODS: We searched PubMed and Embase databases from inception to February 2022 to identify animal studies that compared the effect of CoQ(10) with vehicle treatment or no treatment on myocardial infarct size in models of myocardial I/R injury. Means and standard deviations of the infarct size measurements were pooled as the weighted mean difference with 95% confidence interval (CI) using the random-effects model. Subgroup analyses were also conducted according to animals' species, models' type, and reperfusion time. RESULTS: Six animal studies (4 in vivo and 2 ex vivo) with 116 animals were included. Pooled analysis suggested that CoQ(10) significantly reduced myocardial infarct size by −11.36% (95% CI: −16.82, −5.90, p < 0.0001, I(2) = 94%) compared with the control group. The significance of the pooled effect estimate was maintained in rats, Hartley guinea pigs, and Yorkshire pigs. However, it became insignificant in the subgroup of rabbits −5.29% (95% CI: −27.83, 17.26; I(2) = 87%). Furthermore, CoQ(10) significantly reduced the myocardial infarct size regardless of model type (either in vivo or ex vivo) and reperfusion time (either ≤ 4 h or >4 h). CONCLUSION: Coenzyme Q(10) significantly decreased myocardial infarct size by 11.36% compared with the control group in animal models of myocardial I/R injury. This beneficial action was retained regardless of model type and reperfusion time. |
format | Online Article Text |
id | pubmed-9053645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90536452022-04-30 Coenzyme Q(10) Reduces Infarct Size in Animal Models of Myocardial Ischemia-Reperfusion Injury: A Meta-Analysis and Summary of Underlying Mechanisms Awad, Kamal Sayed, Ahmed Banach, Maciej Front Cardiovasc Med Cardiovascular Medicine OBJECTIVE: Effective interventions that might limit myocardial ischemia-reperfusion (I/R) injury are still lacking. Coenzyme Q(10) (CoQ(10)) may exert cardioprotective actions that reduce myocardial I/R injury. We conducted this meta-analysis to assess the potential cardioprotective effect of CoQ(10) in animal models of myocardial I/R injury. METHODS: We searched PubMed and Embase databases from inception to February 2022 to identify animal studies that compared the effect of CoQ(10) with vehicle treatment or no treatment on myocardial infarct size in models of myocardial I/R injury. Means and standard deviations of the infarct size measurements were pooled as the weighted mean difference with 95% confidence interval (CI) using the random-effects model. Subgroup analyses were also conducted according to animals' species, models' type, and reperfusion time. RESULTS: Six animal studies (4 in vivo and 2 ex vivo) with 116 animals were included. Pooled analysis suggested that CoQ(10) significantly reduced myocardial infarct size by −11.36% (95% CI: −16.82, −5.90, p < 0.0001, I(2) = 94%) compared with the control group. The significance of the pooled effect estimate was maintained in rats, Hartley guinea pigs, and Yorkshire pigs. However, it became insignificant in the subgroup of rabbits −5.29% (95% CI: −27.83, 17.26; I(2) = 87%). Furthermore, CoQ(10) significantly reduced the myocardial infarct size regardless of model type (either in vivo or ex vivo) and reperfusion time (either ≤ 4 h or >4 h). CONCLUSION: Coenzyme Q(10) significantly decreased myocardial infarct size by 11.36% compared with the control group in animal models of myocardial I/R injury. This beneficial action was retained regardless of model type and reperfusion time. Frontiers Media S.A. 2022-04-15 /pmc/articles/PMC9053645/ /pubmed/35498032 http://dx.doi.org/10.3389/fcvm.2022.857364 Text en Copyright © 2022 Awad, Sayed and Banach. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Awad, Kamal Sayed, Ahmed Banach, Maciej Coenzyme Q(10) Reduces Infarct Size in Animal Models of Myocardial Ischemia-Reperfusion Injury: A Meta-Analysis and Summary of Underlying Mechanisms |
title | Coenzyme Q(10) Reduces Infarct Size in Animal Models of Myocardial Ischemia-Reperfusion Injury: A Meta-Analysis and Summary of Underlying Mechanisms |
title_full | Coenzyme Q(10) Reduces Infarct Size in Animal Models of Myocardial Ischemia-Reperfusion Injury: A Meta-Analysis and Summary of Underlying Mechanisms |
title_fullStr | Coenzyme Q(10) Reduces Infarct Size in Animal Models of Myocardial Ischemia-Reperfusion Injury: A Meta-Analysis and Summary of Underlying Mechanisms |
title_full_unstemmed | Coenzyme Q(10) Reduces Infarct Size in Animal Models of Myocardial Ischemia-Reperfusion Injury: A Meta-Analysis and Summary of Underlying Mechanisms |
title_short | Coenzyme Q(10) Reduces Infarct Size in Animal Models of Myocardial Ischemia-Reperfusion Injury: A Meta-Analysis and Summary of Underlying Mechanisms |
title_sort | coenzyme q(10) reduces infarct size in animal models of myocardial ischemia-reperfusion injury: a meta-analysis and summary of underlying mechanisms |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053645/ https://www.ncbi.nlm.nih.gov/pubmed/35498032 http://dx.doi.org/10.3389/fcvm.2022.857364 |
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