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New synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines, acetophenones, and elemental sulfur
A new synthesis of 2-aroylbenzothiazoles via iodine-promoted domino transformations of anilines, acetophenones, and elemental sulfur was demonstrated. The highlights of this tandem synthesis are (1) easily available anilines and acetophenones as feedstock; (2) transition metal-free conditions; (3) i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053705/ https://www.ncbi.nlm.nih.gov/pubmed/35517240 http://dx.doi.org/10.1039/d0ra01750g |
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author | Huynh, Tien V. Doan, Khang V. Luong, Ngoc T. K. Nguyen, Duyen T. P. Doan, Son H. Nguyen, Tung T. Phan, Nam T. S. |
author_facet | Huynh, Tien V. Doan, Khang V. Luong, Ngoc T. K. Nguyen, Duyen T. P. Doan, Son H. Nguyen, Tung T. Phan, Nam T. S. |
author_sort | Huynh, Tien V. |
collection | PubMed |
description | A new synthesis of 2-aroylbenzothiazoles via iodine-promoted domino transformations of anilines, acetophenones, and elemental sulfur was demonstrated. The highlights of this tandem synthesis are (1) easily available anilines and acetophenones as feedstock; (2) transition metal-free conditions; (3) inexpensive, nontoxic, easy handling, and abundant elemental sulfur as a building block. This synthetic strategy would complement the existing methods in the synthesis of this important heterocyclic scaffold. To our best knowledge, the formation of 2-aroylbenzothiazoles from simple anilines, acetophenones, and elemental sulfur was not previously reported in the literature. |
format | Online Article Text |
id | pubmed-9053705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90537052022-05-04 New synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines, acetophenones, and elemental sulfur Huynh, Tien V. Doan, Khang V. Luong, Ngoc T. K. Nguyen, Duyen T. P. Doan, Son H. Nguyen, Tung T. Phan, Nam T. S. RSC Adv Chemistry A new synthesis of 2-aroylbenzothiazoles via iodine-promoted domino transformations of anilines, acetophenones, and elemental sulfur was demonstrated. The highlights of this tandem synthesis are (1) easily available anilines and acetophenones as feedstock; (2) transition metal-free conditions; (3) inexpensive, nontoxic, easy handling, and abundant elemental sulfur as a building block. This synthetic strategy would complement the existing methods in the synthesis of this important heterocyclic scaffold. To our best knowledge, the formation of 2-aroylbenzothiazoles from simple anilines, acetophenones, and elemental sulfur was not previously reported in the literature. The Royal Society of Chemistry 2020-05-14 /pmc/articles/PMC9053705/ /pubmed/35517240 http://dx.doi.org/10.1039/d0ra01750g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Huynh, Tien V. Doan, Khang V. Luong, Ngoc T. K. Nguyen, Duyen T. P. Doan, Son H. Nguyen, Tung T. Phan, Nam T. S. New synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines, acetophenones, and elemental sulfur |
title | New synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines, acetophenones, and elemental sulfur |
title_full | New synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines, acetophenones, and elemental sulfur |
title_fullStr | New synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines, acetophenones, and elemental sulfur |
title_full_unstemmed | New synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines, acetophenones, and elemental sulfur |
title_short | New synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines, acetophenones, and elemental sulfur |
title_sort | new synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines, acetophenones, and elemental sulfur |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053705/ https://www.ncbi.nlm.nih.gov/pubmed/35517240 http://dx.doi.org/10.1039/d0ra01750g |
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