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Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers

Electrospun poly(l)-lactide (PLLA) ultrafine fibers are a biodegradable and biocompatible scaffold, widely used in tissue engineering applications. Unfortunately, these scaffolds have some limitations related to the absence of bioactivity and antibacterial capacity. In this study, dopamine-functiona...

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Autores principales: Li, Biyun, Xiong, Feng, Yao, Bo, Du, Qian, Cao, Jun, Qu, Jiangang, Feng, Wei, Yuan, Huihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053940/
https://www.ncbi.nlm.nih.gov/pubmed/35518341
http://dx.doi.org/10.1039/d0ra03224g
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author Li, Biyun
Xiong, Feng
Yao, Bo
Du, Qian
Cao, Jun
Qu, Jiangang
Feng, Wei
Yuan, Huihua
author_facet Li, Biyun
Xiong, Feng
Yao, Bo
Du, Qian
Cao, Jun
Qu, Jiangang
Feng, Wei
Yuan, Huihua
author_sort Li, Biyun
collection PubMed
description Electrospun poly(l)-lactide (PLLA) ultrafine fibers are a biodegradable and biocompatible scaffold, widely used in tissue engineering applications. Unfortunately, these scaffolds have some limitations related to the absence of bioactivity and antibacterial capacity. In this study, dopamine-functionalized reduced graphene oxide (rGO)/PLLA composite nanofibers were fabricated via electrospinning. The morphology and the physicochemical and biological properties of the composite nanofibers were investigated. The results indicate that incorporating rGO improves the hydrophilic, mechanical, and biocompatibility properties of PLLA nanofibers. Tetracycline hydrochloride (TC)-loaded rGO/PLLA composite nanofibers showed better controlled drug release profiles compared to GO/PLLA and PLLA nanofibrous scaffolds. Drug-loaded nanofibrous scaffolds showed significantly improved antibacterial activity against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus). Additionally, rGO/PLLA composite nanofibers exhibited enhanced cytocompatibility. Thus, it can be concluded that rGO/PLLA composite nanofibers allow the development of multifunctional scaffolds for use in biomedical applications.
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spelling pubmed-90539402022-05-04 Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers Li, Biyun Xiong, Feng Yao, Bo Du, Qian Cao, Jun Qu, Jiangang Feng, Wei Yuan, Huihua RSC Adv Chemistry Electrospun poly(l)-lactide (PLLA) ultrafine fibers are a biodegradable and biocompatible scaffold, widely used in tissue engineering applications. Unfortunately, these scaffolds have some limitations related to the absence of bioactivity and antibacterial capacity. In this study, dopamine-functionalized reduced graphene oxide (rGO)/PLLA composite nanofibers were fabricated via electrospinning. The morphology and the physicochemical and biological properties of the composite nanofibers were investigated. The results indicate that incorporating rGO improves the hydrophilic, mechanical, and biocompatibility properties of PLLA nanofibers. Tetracycline hydrochloride (TC)-loaded rGO/PLLA composite nanofibers showed better controlled drug release profiles compared to GO/PLLA and PLLA nanofibrous scaffolds. Drug-loaded nanofibrous scaffolds showed significantly improved antibacterial activity against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus). Additionally, rGO/PLLA composite nanofibers exhibited enhanced cytocompatibility. Thus, it can be concluded that rGO/PLLA composite nanofibers allow the development of multifunctional scaffolds for use in biomedical applications. The Royal Society of Chemistry 2020-05-15 /pmc/articles/PMC9053940/ /pubmed/35518341 http://dx.doi.org/10.1039/d0ra03224g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Li, Biyun
Xiong, Feng
Yao, Bo
Du, Qian
Cao, Jun
Qu, Jiangang
Feng, Wei
Yuan, Huihua
Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers
title Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers
title_full Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers
title_fullStr Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers
title_full_unstemmed Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers
title_short Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers
title_sort preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/plla composite nanofibers
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053940/
https://www.ncbi.nlm.nih.gov/pubmed/35518341
http://dx.doi.org/10.1039/d0ra03224g
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