Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca(2+) efflux and disrupted by PSEN1 loss of function

Dysfunction and mistrafficking of organelles in autophagy- and endosomal-lysosomal pathways are implicated in neurodegenerative diseases. Here, we reveal selective vulnerability of maturing degradative organelles (late endosomes/amphisomes) to disease-relevant local calcium dysregulation. These orga...

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Detalles Bibliográficos
Autores principales: Lie, Pearl P. Y., Yoo, Lang, Goulbourne, Chris N., Berg, Martin J., Stavrides, Philip, Huo, Chunfeng, Lee, Ju-Hyun, Nixon, Ralph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054012/
https://www.ncbi.nlm.nih.gov/pubmed/35486730
http://dx.doi.org/10.1126/sciadv.abj5716

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