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Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network

The default mode network (DMN) of the brain is functionally associated with a wide range of behaviors. In this study, we used functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and spectral fiber photometry to investigate the selective neuromodulatory effect of norepin...

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Autores principales: Oyarzabal, Esteban A., Hsu, Li-Ming, Das, Manasmita, Chao, Tzu-Hao Harry, Zhou, Jingheng, Song, Sheng, Zhang, Weiting, Smith, Kathleen G., Sciolino, Natale R., Evsyukova, Irina Y., Yuan, Hong, Lee, Sung-Ho, Cui, Guohong, Jensen, Patricia, Shih, Yen-Yu Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054017/
https://www.ncbi.nlm.nih.gov/pubmed/35486721
http://dx.doi.org/10.1126/sciadv.abm9898
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author Oyarzabal, Esteban A.
Hsu, Li-Ming
Das, Manasmita
Chao, Tzu-Hao Harry
Zhou, Jingheng
Song, Sheng
Zhang, Weiting
Smith, Kathleen G.
Sciolino, Natale R.
Evsyukova, Irina Y.
Yuan, Hong
Lee, Sung-Ho
Cui, Guohong
Jensen, Patricia
Shih, Yen-Yu Ian
author_facet Oyarzabal, Esteban A.
Hsu, Li-Ming
Das, Manasmita
Chao, Tzu-Hao Harry
Zhou, Jingheng
Song, Sheng
Zhang, Weiting
Smith, Kathleen G.
Sciolino, Natale R.
Evsyukova, Irina Y.
Yuan, Hong
Lee, Sung-Ho
Cui, Guohong
Jensen, Patricia
Shih, Yen-Yu Ian
author_sort Oyarzabal, Esteban A.
collection PubMed
description The default mode network (DMN) of the brain is functionally associated with a wide range of behaviors. In this study, we used functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and spectral fiber photometry to investigate the selective neuromodulatory effect of norepinephrine (NE)–releasing noradrenergic neurons in the locus coeruleus (LC) on the mouse DMN. Chemogenetic-induced tonic LC activity decreased cerebral blood volume (CBV) and glucose uptake and increased synchronous low-frequency fMRI activity within the frontal cortices of the DMN. Fiber photometry results corroborated these findings, showing that LC-NE activation induced NE release, enhanced calcium-weighted neuronal spiking, and reduced CBV in the anterior cingulate cortex. These data suggest that LC-NE alters conventional coupling between neuronal activity and CBV in the frontal DMN. We also demonstrated that chemogenetic activation of LC-NE neurons strengthened functional connectivity within the frontal DMN, and this effect was causally mediated by reduced modulatory inputs from retrosplenial and hippocampal regions to the association cortices of the DMN.
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spelling pubmed-90540172022-05-04 Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network Oyarzabal, Esteban A. Hsu, Li-Ming Das, Manasmita Chao, Tzu-Hao Harry Zhou, Jingheng Song, Sheng Zhang, Weiting Smith, Kathleen G. Sciolino, Natale R. Evsyukova, Irina Y. Yuan, Hong Lee, Sung-Ho Cui, Guohong Jensen, Patricia Shih, Yen-Yu Ian Sci Adv Neuroscience The default mode network (DMN) of the brain is functionally associated with a wide range of behaviors. In this study, we used functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and spectral fiber photometry to investigate the selective neuromodulatory effect of norepinephrine (NE)–releasing noradrenergic neurons in the locus coeruleus (LC) on the mouse DMN. Chemogenetic-induced tonic LC activity decreased cerebral blood volume (CBV) and glucose uptake and increased synchronous low-frequency fMRI activity within the frontal cortices of the DMN. Fiber photometry results corroborated these findings, showing that LC-NE activation induced NE release, enhanced calcium-weighted neuronal spiking, and reduced CBV in the anterior cingulate cortex. These data suggest that LC-NE alters conventional coupling between neuronal activity and CBV in the frontal DMN. We also demonstrated that chemogenetic activation of LC-NE neurons strengthened functional connectivity within the frontal DMN, and this effect was causally mediated by reduced modulatory inputs from retrosplenial and hippocampal regions to the association cortices of the DMN. American Association for the Advancement of Science 2022-04-29 /pmc/articles/PMC9054017/ /pubmed/35486721 http://dx.doi.org/10.1126/sciadv.abm9898 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Neuroscience
Oyarzabal, Esteban A.
Hsu, Li-Ming
Das, Manasmita
Chao, Tzu-Hao Harry
Zhou, Jingheng
Song, Sheng
Zhang, Weiting
Smith, Kathleen G.
Sciolino, Natale R.
Evsyukova, Irina Y.
Yuan, Hong
Lee, Sung-Ho
Cui, Guohong
Jensen, Patricia
Shih, Yen-Yu Ian
Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network
title Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network
title_full Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network
title_fullStr Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network
title_full_unstemmed Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network
title_short Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network
title_sort chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054017/
https://www.ncbi.nlm.nih.gov/pubmed/35486721
http://dx.doi.org/10.1126/sciadv.abm9898
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