Lipofection with estrone-based luminophores featuring aggregation-induced emission properties

In this communication we present the use of a novel class of luminophores with aggregation-induced emission (AIE) properties based on the steroid estrone. These molecules were equipped with cationic residues yielding amphiphiles suitable for lipofection. To this end, self-assembled luminescent struc...

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Detalles Bibliográficos
Autores principales: Riebe, Steffen, Zimmermann, Alexander, Koch, Johannes, Vallet, Cecilia, Knauer, Shirley K., Sowa, Andrea, Wölper, Christoph, Voskuhl, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054052/
https://www.ncbi.nlm.nih.gov/pubmed/35515436
http://dx.doi.org/10.1039/d0ra03608k
Descripción
Sumario:In this communication we present the use of a novel class of luminophores with aggregation-induced emission (AIE) properties based on the steroid estrone. These molecules were equipped with cationic residues yielding amphiphiles suitable for lipofection. To this end, self-assembled luminescent structures were formed in aqueous media and mixed with a red-fluorescent protein expressing plasmid, yielding lipoplexes with increased emission intensity. These luminescent lipoplexes were able to efficiently transfect HeLa and HEK 293T cells and were able to be tracked due to the aggregation induced-emission properties.

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