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Clinical effect of vitamin C supplementation on bone healing: A systematic review

BACKGROUND: The aim of the present systematic review was to evaluate the clinical effect of vitamin C on bone healing after bone fracture or bone reconstruction procedures. MATERIAL AND METHODS: In October 2020, Cochrane Library, Scopus and PubMed-Medline databases were searched without restrictions...

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Autores principales: Barrios-Garay, Kevin, Toledano-Serrabona, Jorge, Gay-Escoda, Cosme, Sánchez-Garcés, Mª Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054165/
https://www.ncbi.nlm.nih.gov/pubmed/35368012
http://dx.doi.org/10.4317/medoral.24944
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author Barrios-Garay, Kevin
Toledano-Serrabona, Jorge
Gay-Escoda, Cosme
Sánchez-Garcés, Mª Ángeles
author_facet Barrios-Garay, Kevin
Toledano-Serrabona, Jorge
Gay-Escoda, Cosme
Sánchez-Garcés, Mª Ángeles
author_sort Barrios-Garay, Kevin
collection PubMed
description BACKGROUND: The aim of the present systematic review was to evaluate the clinical effect of vitamin C on bone healing after bone fracture or bone reconstruction procedures. MATERIAL AND METHODS: In October 2020, Cochrane Library, Scopus and PubMed-Medline databases were searched without restrictions to identify animal and human studies that fulfilled the eligibility criteria. Outcome measures were bone healing time, bone gain (mm), bone density and adverse events. The risk of bias assessment of the selected studies was evaluated by means of Cochrane Collaboration’s Tool for randomized clinical trials, while randomized clinical animal trials were assessed according to SYRCLE’s tool. Additionally, quality of reporting animal studies were assessed according to ARRIVE guidelines. RESULTS: Out of the 248 articles that yielded the initial search, 11 papers about the effect of ascorbic acid on bone healing were selected. In most of the animal studies, vitamin C seemed to accelerate bone formation owing to an enhanced osteoblastic proliferation and differentiation and its antioxidant function when pro-oxidant substances were added. It was not possible to observe this phenomenon in human studies. CONCLUSIONS: Although additional well-performed animal and human studies are required, vitamin C seems to accelerate bone regeneration without adverse events. However, it is not possible to recommend a specific dose or route of administration of vitamin C to improve the bone healing process in humans as there was great heterogeneity among the included studies. Key words:Vitamin C, Fracture healing, Bone regeneration, Bone mineral density, Implants.
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spelling pubmed-90541652022-05-05 Clinical effect of vitamin C supplementation on bone healing: A systematic review Barrios-Garay, Kevin Toledano-Serrabona, Jorge Gay-Escoda, Cosme Sánchez-Garcés, Mª Ángeles Med Oral Patol Oral Cir Bucal Review BACKGROUND: The aim of the present systematic review was to evaluate the clinical effect of vitamin C on bone healing after bone fracture or bone reconstruction procedures. MATERIAL AND METHODS: In October 2020, Cochrane Library, Scopus and PubMed-Medline databases were searched without restrictions to identify animal and human studies that fulfilled the eligibility criteria. Outcome measures were bone healing time, bone gain (mm), bone density and adverse events. The risk of bias assessment of the selected studies was evaluated by means of Cochrane Collaboration’s Tool for randomized clinical trials, while randomized clinical animal trials were assessed according to SYRCLE’s tool. Additionally, quality of reporting animal studies were assessed according to ARRIVE guidelines. RESULTS: Out of the 248 articles that yielded the initial search, 11 papers about the effect of ascorbic acid on bone healing were selected. In most of the animal studies, vitamin C seemed to accelerate bone formation owing to an enhanced osteoblastic proliferation and differentiation and its antioxidant function when pro-oxidant substances were added. It was not possible to observe this phenomenon in human studies. CONCLUSIONS: Although additional well-performed animal and human studies are required, vitamin C seems to accelerate bone regeneration without adverse events. However, it is not possible to recommend a specific dose or route of administration of vitamin C to improve the bone healing process in humans as there was great heterogeneity among the included studies. Key words:Vitamin C, Fracture healing, Bone regeneration, Bone mineral density, Implants. Medicina Oral S.L. 2022-05 2022-04-03 /pmc/articles/PMC9054165/ /pubmed/35368012 http://dx.doi.org/10.4317/medoral.24944 Text en Copyright: © 2022 Medicina Oral S.L. https://creativecommons.org/licenses/by/2.5/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Barrios-Garay, Kevin
Toledano-Serrabona, Jorge
Gay-Escoda, Cosme
Sánchez-Garcés, Mª Ángeles
Clinical effect of vitamin C supplementation on bone healing: A systematic review
title Clinical effect of vitamin C supplementation on bone healing: A systematic review
title_full Clinical effect of vitamin C supplementation on bone healing: A systematic review
title_fullStr Clinical effect of vitamin C supplementation on bone healing: A systematic review
title_full_unstemmed Clinical effect of vitamin C supplementation on bone healing: A systematic review
title_short Clinical effect of vitamin C supplementation on bone healing: A systematic review
title_sort clinical effect of vitamin c supplementation on bone healing: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054165/
https://www.ncbi.nlm.nih.gov/pubmed/35368012
http://dx.doi.org/10.4317/medoral.24944
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