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Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis
BACKGROUND: New prevention strategies have been advocated to control the progression of HIV/AIDS, such as preexposure prophylaxis (PrEP). The aim of this study is to evaluate the potential changes in the oral and salivary conditions of HIV-uninfected subjects using PrEP. MATERIAL AND METHODS: Subjec...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medicina Oral S.L.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054169/ https://www.ncbi.nlm.nih.gov/pubmed/35368014 http://dx.doi.org/10.4317/medoral.25140 |
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author | Macedo, Nayara Baggio, Gabriela Henn, Indiara Santos, Juliane Batista, Thiago Ignácio, Sérgio Souza, Paulo Azevedo-Alanis, Luciana |
author_facet | Macedo, Nayara Baggio, Gabriela Henn, Indiara Santos, Juliane Batista, Thiago Ignácio, Sérgio Souza, Paulo Azevedo-Alanis, Luciana |
author_sort | Macedo, Nayara |
collection | PubMed |
description | BACKGROUND: New prevention strategies have been advocated to control the progression of HIV/AIDS, such as preexposure prophylaxis (PrEP). The aim of this study is to evaluate the potential changes in the oral and salivary conditions of HIV-uninfected subjects using PrEP. MATERIAL AND METHODS: Subjects were evaluated before beginning the medication (T0), at the first follow-up (T1), and at the second follow-up (T2). Xerostomia, presence of untreated cavitated caries, oral hygiene habits, taste, gingival and plaque index, stimulated salivary flow rate (SSFR), and salivary concentrations of calcium, glucose, urea, and total proteins were evaluated. Data obtained were analyzed using statistical tests (p<0.05). RESULTS: Forty-seven participants (41 men; 6 women) were evaluated at T0. Thirty (28 men; 2 women) and 17 men were reassessed at T1 and T2, respectively. There was no difference between the SSFR and oral and salivary conditions between T0, T1, and T2 (p>0.05), except for the salivary calcium concentration, that increased at T2 compared to T1 (p=0.02). There was significant difference between taste and xerostomia at T1 (p=0.017), and the need to drink to swallow at T2 (p=0.015). There was significant correlation between the reported amount of saliva and taste (p=0.039, r=-0.378) at T1. CONCLUSIONS: The prolonged use of PrEP seems to be associated with reports of dry mouth and worsening of taste, possibly associated with increased salivary calcium concentration. Key words:Antiretroviral agents, pre-exposure prophylaxis, saliva, oral health. |
format | Online Article Text |
id | pubmed-9054169 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90541692022-05-05 Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis Macedo, Nayara Baggio, Gabriela Henn, Indiara Santos, Juliane Batista, Thiago Ignácio, Sérgio Souza, Paulo Azevedo-Alanis, Luciana Med Oral Patol Oral Cir Bucal Research BACKGROUND: New prevention strategies have been advocated to control the progression of HIV/AIDS, such as preexposure prophylaxis (PrEP). The aim of this study is to evaluate the potential changes in the oral and salivary conditions of HIV-uninfected subjects using PrEP. MATERIAL AND METHODS: Subjects were evaluated before beginning the medication (T0), at the first follow-up (T1), and at the second follow-up (T2). Xerostomia, presence of untreated cavitated caries, oral hygiene habits, taste, gingival and plaque index, stimulated salivary flow rate (SSFR), and salivary concentrations of calcium, glucose, urea, and total proteins were evaluated. Data obtained were analyzed using statistical tests (p<0.05). RESULTS: Forty-seven participants (41 men; 6 women) were evaluated at T0. Thirty (28 men; 2 women) and 17 men were reassessed at T1 and T2, respectively. There was no difference between the SSFR and oral and salivary conditions between T0, T1, and T2 (p>0.05), except for the salivary calcium concentration, that increased at T2 compared to T1 (p=0.02). There was significant difference between taste and xerostomia at T1 (p=0.017), and the need to drink to swallow at T2 (p=0.015). There was significant correlation between the reported amount of saliva and taste (p=0.039, r=-0.378) at T1. CONCLUSIONS: The prolonged use of PrEP seems to be associated with reports of dry mouth and worsening of taste, possibly associated with increased salivary calcium concentration. Key words:Antiretroviral agents, pre-exposure prophylaxis, saliva, oral health. Medicina Oral S.L. 2022-05 2022-04-03 /pmc/articles/PMC9054169/ /pubmed/35368014 http://dx.doi.org/10.4317/medoral.25140 Text en Copyright: © 2022 Medicina Oral S.L. https://creativecommons.org/licenses/by/2.5/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Macedo, Nayara Baggio, Gabriela Henn, Indiara Santos, Juliane Batista, Thiago Ignácio, Sérgio Souza, Paulo Azevedo-Alanis, Luciana Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis |
title | Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis |
title_full | Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis |
title_fullStr | Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis |
title_full_unstemmed | Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis |
title_short | Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis |
title_sort | oral conditions and salivary analysis in hiv-uninfected subjects using preexposure prophylaxis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054169/ https://www.ncbi.nlm.nih.gov/pubmed/35368014 http://dx.doi.org/10.4317/medoral.25140 |
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