Controlled delivery of a protein tyrosine phosphatase inhibitor, SHP099, using cyclodextrin-mediated host–guest interactions in polyelectrolyte multilayer films for cancer therapy

The Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) is a key enzyme in pathways regulating tumor growth signaling, and recently gained interest as a promising anticancer drug target. Many SHP2 inhibitors are currently under development, including SHP099, which has shown potent...

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Detalles Bibliográficos
Autores principales: Wang, Soobin, Battigelli, Alessia, Alkekhia, Dahlia, Fairman, Alexis, Antoci, Valentin, Yang, Wentian, Moore, Douglas, Shukla, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054207/
https://www.ncbi.nlm.nih.gov/pubmed/35520441
http://dx.doi.org/10.1039/d0ra03864d

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