Synthesis and properties of a temperature-sensitive hydrogel based on physical crosslinking via stereocomplexation of PLLA-PDLA

A synthetic route to amphiphilic conetwork (APCN) gels was developed and involved (1) a ring-opening polymerization (ROP) synthesis of the macromonomer HEMA-PLLA/PDLA, and (2) a radical polymerization of a stereocomplex of the synthesized macromonomers with P(MEO(2)MA-co-OEGMA) to form the APCN gels. The structure of the gel was successfully verified using X-ray diffraction. Thermal analysis and differential scanning calorimetry data showed that the thermal behaviors of the gels were greatly improved compared with that of polylactic acid (PLA). The mechanical properties of the gels were measured by using a dynamic viscometer, and the results indicated a greater mechanical strength before swelling than afterwards, and an increasing strength of the gels with increasing amount of PLA stereocomplex. Gels placed in different aqueous phases at different temperatures showed different swelling ratio (SR) values. Specifically, the SR gradually decreased as the temperature was increased, indicating a temperature sensitivity of the gels. In addition, the gels placed in the aqueous and organic phases presented as hydrogels and hydrophobic gels, respectively, and their SR values were relatively low. These results indicated the amphiphilic nature of the gel, and indicated great application prospects for the gel in biomedicine.