Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes

Catalytic methods for the synthesis of previously unknown 2,9-disubstituted 3bR*,7aR*,10bR*,14aR*-cis-14c,14d-perhydro-2,3a,7b,9,10a,14b-hexaazadibenzotetracenes have been developed. The structures were established by 1D ((1)H, (13)C) and 2D (COSY, HSQC, HMBC) NMR spectroscopy, MALDI TOF/TOF mass sp...

Descripción completa

Detalles Bibliográficos
Autores principales: Rakhimova, Elena B., Kirsanov, Victor Yu., Tret'yakova, Elena V., Khalilov, Leonard M., Ibragimov, Askhat G., Dzhemileva, Lilya U., D'yakonov, Vladimir A., Dzhemilev, Usein M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054349/
https://www.ncbi.nlm.nih.gov/pubmed/35518764
http://dx.doi.org/10.1039/d0ra03209c
_version_ 1784697166723284992
author Rakhimova, Elena B.
Kirsanov, Victor Yu.
Tret'yakova, Elena V.
Khalilov, Leonard M.
Ibragimov, Askhat G.
Dzhemileva, Lilya U.
D'yakonov, Vladimir A.
Dzhemilev, Usein M.
author_facet Rakhimova, Elena B.
Kirsanov, Victor Yu.
Tret'yakova, Elena V.
Khalilov, Leonard M.
Ibragimov, Askhat G.
Dzhemileva, Lilya U.
D'yakonov, Vladimir A.
Dzhemilev, Usein M.
author_sort Rakhimova, Elena B.
collection PubMed
description Catalytic methods for the synthesis of previously unknown 2,9-disubstituted 3bR*,7aR*,10bR*,14aR*-cis-14c,14d-perhydro-2,3a,7b,9,10a,14b-hexaazadibenzotetracenes have been developed. The structures were established by 1D ((1)H, (13)C) and 2D (COSY, HSQC, HMBC) NMR spectroscopy, MALDI TOF/TOF mass spectrometry, and X-ray diffraction analysis. Primary screening of the synthesized perhydro hexaazadibenzotetracenes for antitumor activity was carried out.
format Online
Article
Text
id pubmed-9054349
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90543492022-05-04 Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes Rakhimova, Elena B. Kirsanov, Victor Yu. Tret'yakova, Elena V. Khalilov, Leonard M. Ibragimov, Askhat G. Dzhemileva, Lilya U. D'yakonov, Vladimir A. Dzhemilev, Usein M. RSC Adv Chemistry Catalytic methods for the synthesis of previously unknown 2,9-disubstituted 3bR*,7aR*,10bR*,14aR*-cis-14c,14d-perhydro-2,3a,7b,9,10a,14b-hexaazadibenzotetracenes have been developed. The structures were established by 1D ((1)H, (13)C) and 2D (COSY, HSQC, HMBC) NMR spectroscopy, MALDI TOF/TOF mass spectrometry, and X-ray diffraction analysis. Primary screening of the synthesized perhydro hexaazadibenzotetracenes for antitumor activity was carried out. The Royal Society of Chemistry 2020-06-04 /pmc/articles/PMC9054349/ /pubmed/35518764 http://dx.doi.org/10.1039/d0ra03209c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Rakhimova, Elena B.
Kirsanov, Victor Yu.
Tret'yakova, Elena V.
Khalilov, Leonard M.
Ibragimov, Askhat G.
Dzhemileva, Lilya U.
D'yakonov, Vladimir A.
Dzhemilev, Usein M.
Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes
title Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes
title_full Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes
title_fullStr Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes
title_full_unstemmed Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes
title_short Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes
title_sort synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054349/
https://www.ncbi.nlm.nih.gov/pubmed/35518764
http://dx.doi.org/10.1039/d0ra03209c
work_keys_str_mv AT rakhimovaelenab synthesisstructureandantitumoractivityof29disubstitutedperhydro23a7b910a14bhexaazadibenzotetracenes
AT kirsanovvictoryu synthesisstructureandantitumoractivityof29disubstitutedperhydro23a7b910a14bhexaazadibenzotetracenes
AT tretyakovaelenav synthesisstructureandantitumoractivityof29disubstitutedperhydro23a7b910a14bhexaazadibenzotetracenes
AT khalilovleonardm synthesisstructureandantitumoractivityof29disubstitutedperhydro23a7b910a14bhexaazadibenzotetracenes
AT ibragimovaskhatg synthesisstructureandantitumoractivityof29disubstitutedperhydro23a7b910a14bhexaazadibenzotetracenes
AT dzhemilevalilyau synthesisstructureandantitumoractivityof29disubstitutedperhydro23a7b910a14bhexaazadibenzotetracenes
AT dyakonovvladimira synthesisstructureandantitumoractivityof29disubstitutedperhydro23a7b910a14bhexaazadibenzotetracenes
AT dzhemilevuseinm synthesisstructureandantitumoractivityof29disubstitutedperhydro23a7b910a14bhexaazadibenzotetracenes

Ejemplares similares