Rh(iii)-catalyzed spiroannulation of 3-arylquinoxalin-2(1H)-ones with alkynes: practical access to spiroquinoxalinones

The Rh(iii)-catalyzed synthesis of spiroquinoxalinone derivatives from 3-arylquinoxalin-2(1H)-ones and alkynes via a C–H functionalization/[3 + 2] annulation sequence has been developed. This method, featuring low catalyst loading, was amenable to Gram scale synthesis and tolerated a variety of func...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yuanfei, Huang, Ting, Li, Xinghua, Zhang, Min, Song, Ying, Huang, Kelin, Su, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054490/
https://www.ncbi.nlm.nih.gov/pubmed/35516638
http://dx.doi.org/10.1039/d0ra03348k
_version_ 1784697199254306816
author Zhang, Yuanfei
Huang, Ting
Li, Xinghua
Zhang, Min
Song, Ying
Huang, Kelin
Su, Weiping
author_facet Zhang, Yuanfei
Huang, Ting
Li, Xinghua
Zhang, Min
Song, Ying
Huang, Kelin
Su, Weiping
author_sort Zhang, Yuanfei
collection PubMed
description The Rh(iii)-catalyzed synthesis of spiroquinoxalinone derivatives from 3-arylquinoxalin-2(1H)-ones and alkynes via a C–H functionalization/[3 + 2] annulation sequence has been developed. This method, featuring low catalyst loading, was amenable to Gram scale synthesis and tolerated a variety of functional groups and substitution patterns on the aryl rings, providing the target products in good to excellent yields.
format Online
Article
Text
id pubmed-9054490
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90544902022-05-04 Rh(iii)-catalyzed spiroannulation of 3-arylquinoxalin-2(1H)-ones with alkynes: practical access to spiroquinoxalinones Zhang, Yuanfei Huang, Ting Li, Xinghua Zhang, Min Song, Ying Huang, Kelin Su, Weiping RSC Adv Chemistry The Rh(iii)-catalyzed synthesis of spiroquinoxalinone derivatives from 3-arylquinoxalin-2(1H)-ones and alkynes via a C–H functionalization/[3 + 2] annulation sequence has been developed. This method, featuring low catalyst loading, was amenable to Gram scale synthesis and tolerated a variety of functional groups and substitution patterns on the aryl rings, providing the target products in good to excellent yields. The Royal Society of Chemistry 2020-06-10 /pmc/articles/PMC9054490/ /pubmed/35516638 http://dx.doi.org/10.1039/d0ra03348k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhang, Yuanfei
Huang, Ting
Li, Xinghua
Zhang, Min
Song, Ying
Huang, Kelin
Su, Weiping
Rh(iii)-catalyzed spiroannulation of 3-arylquinoxalin-2(1H)-ones with alkynes: practical access to spiroquinoxalinones
title Rh(iii)-catalyzed spiroannulation of 3-arylquinoxalin-2(1H)-ones with alkynes: practical access to spiroquinoxalinones
title_full Rh(iii)-catalyzed spiroannulation of 3-arylquinoxalin-2(1H)-ones with alkynes: practical access to spiroquinoxalinones
title_fullStr Rh(iii)-catalyzed spiroannulation of 3-arylquinoxalin-2(1H)-ones with alkynes: practical access to spiroquinoxalinones
title_full_unstemmed Rh(iii)-catalyzed spiroannulation of 3-arylquinoxalin-2(1H)-ones with alkynes: practical access to spiroquinoxalinones
title_short Rh(iii)-catalyzed spiroannulation of 3-arylquinoxalin-2(1H)-ones with alkynes: practical access to spiroquinoxalinones
title_sort rh(iii)-catalyzed spiroannulation of 3-arylquinoxalin-2(1h)-ones with alkynes: practical access to spiroquinoxalinones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054490/
https://www.ncbi.nlm.nih.gov/pubmed/35516638
http://dx.doi.org/10.1039/d0ra03348k
work_keys_str_mv AT zhangyuanfei rhiiicatalyzedspiroannulationof3arylquinoxalin21honeswithalkynespracticalaccesstospiroquinoxalinones
AT huangting rhiiicatalyzedspiroannulationof3arylquinoxalin21honeswithalkynespracticalaccesstospiroquinoxalinones
AT lixinghua rhiiicatalyzedspiroannulationof3arylquinoxalin21honeswithalkynespracticalaccesstospiroquinoxalinones
AT zhangmin rhiiicatalyzedspiroannulationof3arylquinoxalin21honeswithalkynespracticalaccesstospiroquinoxalinones
AT songying rhiiicatalyzedspiroannulationof3arylquinoxalin21honeswithalkynespracticalaccesstospiroquinoxalinones
AT huangkelin rhiiicatalyzedspiroannulationof3arylquinoxalin21honeswithalkynespracticalaccesstospiroquinoxalinones
AT suweiping rhiiicatalyzedspiroannulationof3arylquinoxalin21honeswithalkynespracticalaccesstospiroquinoxalinones

Ejemplares similares