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Synthesis and molecular modeling studies of cholinesterase inhibitor dispiro[indoline-3,2′-pyrrolidine-3′,3′′-pyrrolidines]

A set of dispiro[indoline-3,2′-pyrrolidine-3′,3′′-pyrrolidines] 8a–l was regioselectively synthesized utilizing multi-component azomethine cycloaddition reaction of 3-(arylmethylidene)pyrrolidine-2,5-diones 5a–e, isatins 6a–c and sarcosine 7. Single crystal X-ray studies of 8c add conclusive support...

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Detalles Bibliográficos
Autores principales:	Youssef, M. Adel, Panda, Siva S., El-Shiekh, Riham A., Shalaby, ElSayed M., Aboshouk, Dalia R., Fayad, Walid, Fawzy, Nehmedo G., Girgis, Adel S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054546/ https://www.ncbi.nlm.nih.gov/pubmed/35516607 http://dx.doi.org/10.1039/d0ra03064c

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