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The development of novel bioactive porous titanium as a bone reconstruction material

Porous titanium fabricated by the resin-impregnated titanium substitute technique has good mechanical strength and osteoconduction. The alkali treatment of the titanium surface creates a bioactive surface. Alkali-treated porous titanium is expected to accelerate bone formation. The purpose of this s...

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Autores principales: Doi, Kazuya, Kobatake, Reiko, Makihara, Yusuke, Oki, Yoshifumi, Umehara, Hanako, Kubo, Takayasu, Tsuga, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054584/
https://www.ncbi.nlm.nih.gov/pubmed/35514562
http://dx.doi.org/10.1039/d0ra03202f
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author Doi, Kazuya
Kobatake, Reiko
Makihara, Yusuke
Oki, Yoshifumi
Umehara, Hanako
Kubo, Takayasu
Tsuga, Kazuhiro
author_facet Doi, Kazuya
Kobatake, Reiko
Makihara, Yusuke
Oki, Yoshifumi
Umehara, Hanako
Kubo, Takayasu
Tsuga, Kazuhiro
author_sort Doi, Kazuya
collection PubMed
description Porous titanium fabricated by the resin-impregnated titanium substitute technique has good mechanical strength and osteoconduction. The alkali treatment of the titanium surface creates a bioactive surface. Alkali-treated porous titanium is expected to accelerate bone formation. The purpose of this study was to evaluate the bone reconstruction ability of alkali-treated porous titanium. Porous titanium (85% porosity) was treated with an alkali solution (5 N NaOH, 24 h). To assess material properties, we analyzed the surface structure by scanning electron microscopy (SEM) and mechanical strength testing. To assess bioactivity, each sample was soaked in a simulated body fluid (Hank's solution) for 7 days. Surface observations, weight change ratio measurement (after/before being soaked in Hank's solution) and surface elemental analysis were performed. We also designed an in vivo study with rabbit femurs. After 2 and 3 weeks of implantation, histological observations and histomorphometric bone formation ratio analysis were performed. All data were statistically analyzed using a Student's t-test (P < 0.05) (this study was approved by the Hiroshima University animal experiment ethics committee: A11-5-5). Non-treated porous titanium (control) appeared to have a smooth surface and the alkali-treated porous titanium (ATPT) had a nano-sized needle-like rough surface. ATPT had similar mechanical strength to that of the control. After soaking into the Hank's solution, we observed apatite-like crystals in the SEM image, weight gain, and high Ca and P contents in ATPT. There was significant bone formation at an early stage in ATPT compared with that in control. It was suggested that the alkali-treated porous titanium had a bioactive surface and induced bone reconstruction effectively. This novel bioactive porous titanium can be expected to be a good bone reconstruction material.
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spelling pubmed-90545842022-05-04 The development of novel bioactive porous titanium as a bone reconstruction material Doi, Kazuya Kobatake, Reiko Makihara, Yusuke Oki, Yoshifumi Umehara, Hanako Kubo, Takayasu Tsuga, Kazuhiro RSC Adv Chemistry Porous titanium fabricated by the resin-impregnated titanium substitute technique has good mechanical strength and osteoconduction. The alkali treatment of the titanium surface creates a bioactive surface. Alkali-treated porous titanium is expected to accelerate bone formation. The purpose of this study was to evaluate the bone reconstruction ability of alkali-treated porous titanium. Porous titanium (85% porosity) was treated with an alkali solution (5 N NaOH, 24 h). To assess material properties, we analyzed the surface structure by scanning electron microscopy (SEM) and mechanical strength testing. To assess bioactivity, each sample was soaked in a simulated body fluid (Hank's solution) for 7 days. Surface observations, weight change ratio measurement (after/before being soaked in Hank's solution) and surface elemental analysis were performed. We also designed an in vivo study with rabbit femurs. After 2 and 3 weeks of implantation, histological observations and histomorphometric bone formation ratio analysis were performed. All data were statistically analyzed using a Student's t-test (P < 0.05) (this study was approved by the Hiroshima University animal experiment ethics committee: A11-5-5). Non-treated porous titanium (control) appeared to have a smooth surface and the alkali-treated porous titanium (ATPT) had a nano-sized needle-like rough surface. ATPT had similar mechanical strength to that of the control. After soaking into the Hank's solution, we observed apatite-like crystals in the SEM image, weight gain, and high Ca and P contents in ATPT. There was significant bone formation at an early stage in ATPT compared with that in control. It was suggested that the alkali-treated porous titanium had a bioactive surface and induced bone reconstruction effectively. This novel bioactive porous titanium can be expected to be a good bone reconstruction material. The Royal Society of Chemistry 2020-06-12 /pmc/articles/PMC9054584/ /pubmed/35514562 http://dx.doi.org/10.1039/d0ra03202f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Doi, Kazuya
Kobatake, Reiko
Makihara, Yusuke
Oki, Yoshifumi
Umehara, Hanako
Kubo, Takayasu
Tsuga, Kazuhiro
The development of novel bioactive porous titanium as a bone reconstruction material
title The development of novel bioactive porous titanium as a bone reconstruction material
title_full The development of novel bioactive porous titanium as a bone reconstruction material
title_fullStr The development of novel bioactive porous titanium as a bone reconstruction material
title_full_unstemmed The development of novel bioactive porous titanium as a bone reconstruction material
title_short The development of novel bioactive porous titanium as a bone reconstruction material
title_sort development of novel bioactive porous titanium as a bone reconstruction material
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054584/
https://www.ncbi.nlm.nih.gov/pubmed/35514562
http://dx.doi.org/10.1039/d0ra03202f
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