New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells

Seven previously undescribed withanolides, namely physaminilide A–G (1–7), and two artificial withanolides (8–9), along with 10 known analogues (10–19) were isolated from Physalis minima. The structures were established by spectroscopic analysis, including NMR and electronic circular dichroism (ECD)...

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Detalles Bibliográficos
Autores principales: Zhang, Meng, Zhang, Bingyang, Guang, Chenxi, Jiang, Benke, He, Xinya, Cao, Shijie, Ding, Liqin, Kang, Ning, Chen, Lixia, Qiu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054647/
https://www.ncbi.nlm.nih.gov/pubmed/35514550
http://dx.doi.org/10.1039/d0ra04106h
Descripción
Sumario:Seven previously undescribed withanolides, namely physaminilide A–G (1–7), and two artificial withanolides (8–9), along with 10 known analogues (10–19) were isolated from Physalis minima. The structures were established by spectroscopic analysis, including NMR and electronic circular dichroism (ECD) data. Cytotoxicity of all the isolates was evaluated against A375 human melanoma cells. Compounds 2, 5, 8, 10, 11 and 15 exhibited significant cytotoxic activities with IC(50) values in the range of 1.2–9.4 μM.

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