New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells

Seven previously undescribed withanolides, namely physaminilide A–G (1–7), and two artificial withanolides (8–9), along with 10 known analogues (10–19) were isolated from Physalis minima. The structures were established by spectroscopic analysis, including NMR and electronic circular dichroism (ECD)...

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Autores principales: Zhang, Meng, Zhang, Bingyang, Guang, Chenxi, Jiang, Benke, He, Xinya, Cao, Shijie, Ding, Liqin, Kang, Ning, Chen, Lixia, Qiu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054647/
https://www.ncbi.nlm.nih.gov/pubmed/35514550
http://dx.doi.org/10.1039/d0ra04106h
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author Zhang, Meng
Zhang, Bingyang
Guang, Chenxi
Jiang, Benke
He, Xinya
Cao, Shijie
Ding, Liqin
Kang, Ning
Chen, Lixia
Qiu, Feng
author_facet Zhang, Meng
Zhang, Bingyang
Guang, Chenxi
Jiang, Benke
He, Xinya
Cao, Shijie
Ding, Liqin
Kang, Ning
Chen, Lixia
Qiu, Feng
author_sort Zhang, Meng
collection PubMed
description Seven previously undescribed withanolides, namely physaminilide A–G (1–7), and two artificial withanolides (8–9), along with 10 known analogues (10–19) were isolated from Physalis minima. The structures were established by spectroscopic analysis, including NMR and electronic circular dichroism (ECD) data. Cytotoxicity of all the isolates was evaluated against A375 human melanoma cells. Compounds 2, 5, 8, 10, 11 and 15 exhibited significant cytotoxic activities with IC(50) values in the range of 1.2–9.4 μM.
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spelling pubmed-90546472022-05-04 New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells Zhang, Meng Zhang, Bingyang Guang, Chenxi Jiang, Benke He, Xinya Cao, Shijie Ding, Liqin Kang, Ning Chen, Lixia Qiu, Feng RSC Adv Chemistry Seven previously undescribed withanolides, namely physaminilide A–G (1–7), and two artificial withanolides (8–9), along with 10 known analogues (10–19) were isolated from Physalis minima. The structures were established by spectroscopic analysis, including NMR and electronic circular dichroism (ECD) data. Cytotoxicity of all the isolates was evaluated against A375 human melanoma cells. Compounds 2, 5, 8, 10, 11 and 15 exhibited significant cytotoxic activities with IC(50) values in the range of 1.2–9.4 μM. The Royal Society of Chemistry 2020-06-16 /pmc/articles/PMC9054647/ /pubmed/35514550 http://dx.doi.org/10.1039/d0ra04106h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhang, Meng
Zhang, Bingyang
Guang, Chenxi
Jiang, Benke
He, Xinya
Cao, Shijie
Ding, Liqin
Kang, Ning
Chen, Lixia
Qiu, Feng
New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells
title New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells
title_full New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells
title_fullStr New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells
title_full_unstemmed New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells
title_short New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells
title_sort new withanolides from physalis minima and their cytotoxicity against a375 human melanoma cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054647/
https://www.ncbi.nlm.nih.gov/pubmed/35514550
http://dx.doi.org/10.1039/d0ra04106h
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