Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1

Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor with high susceptibility to metastasize. The underlying molecular mechanisms leading to EWS metastases remain poorly understood. Epigenetic changes have been implicated in EWS tumor growth and progression. Linking epigenetics and metast...

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Detalles Bibliográficos
Autores principales: García-Domínguez, Daniel J., Hajji, Nabil, López-Alemany, Roser, Sánchez-Molina, Sara, Figuerola-Bou, Elisabet, Morón Civanto, Francisco J., Rello-Varona, Santiago, Andrés-León, Eduardo, Benito, Adrián, Keun, Hector C., Mora, Jaume, Tirado, Óscar M., de Álava, Enrique, Hontecillas-Prieto, Lourdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054661/
https://www.ncbi.nlm.nih.gov/pubmed/35354905
http://dx.doi.org/10.1038/s41388-022-02279-w

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