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High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids
Ionic liquids (ILs) have been employed as potentially environmentally friendly replacements for harmful organic solvents, but have also been studied for their use in bioelectrochemical applications, such as in microbial electrochemistry for bioenergy production, or in industrial biocatalysis. For th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054695/ https://www.ncbi.nlm.nih.gov/pubmed/35520299 http://dx.doi.org/10.1039/d0ra03107k |
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author | Tether, Angela L. Laverty, Garry Puga, Alberto V. Seddon, Kenneth R. Gilmore, Brendan F. Kelly, Stephen A. |
author_facet | Tether, Angela L. Laverty, Garry Puga, Alberto V. Seddon, Kenneth R. Gilmore, Brendan F. Kelly, Stephen A. |
author_sort | Tether, Angela L. |
collection | PubMed |
description | Ionic liquids (ILs) have been employed as potentially environmentally friendly replacements for harmful organic solvents, but have also been studied for their use in bioelectrochemical applications, such as in microbial electrochemistry for bioenergy production, or in industrial biocatalysis. For these processes, low microbial toxicity is important and there is a growing need for microbial toxicology studies for novel ILs. In this study, we report initial toxicity data for novel ILs, based on azepanium and 3-methylpiperidinium cations. Agar disc diffusion assays are used, along with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) determinations, to obtain rapid and inexpensive initial toxicity data for these novel ILs against Escherichia coli and Staphylococcus epidermidis. Many of the novel ILs characterised possess low microbial toxicity relative to well-studied ILs, highlighting their potential for further study in applications where this is a desirable property. |
format | Online Article Text |
id | pubmed-9054695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90546952022-05-04 High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids Tether, Angela L. Laverty, Garry Puga, Alberto V. Seddon, Kenneth R. Gilmore, Brendan F. Kelly, Stephen A. RSC Adv Chemistry Ionic liquids (ILs) have been employed as potentially environmentally friendly replacements for harmful organic solvents, but have also been studied for their use in bioelectrochemical applications, such as in microbial electrochemistry for bioenergy production, or in industrial biocatalysis. For these processes, low microbial toxicity is important and there is a growing need for microbial toxicology studies for novel ILs. In this study, we report initial toxicity data for novel ILs, based on azepanium and 3-methylpiperidinium cations. Agar disc diffusion assays are used, along with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) determinations, to obtain rapid and inexpensive initial toxicity data for these novel ILs against Escherichia coli and Staphylococcus epidermidis. Many of the novel ILs characterised possess low microbial toxicity relative to well-studied ILs, highlighting their potential for further study in applications where this is a desirable property. The Royal Society of Chemistry 2020-06-16 /pmc/articles/PMC9054695/ /pubmed/35520299 http://dx.doi.org/10.1039/d0ra03107k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Tether, Angela L. Laverty, Garry Puga, Alberto V. Seddon, Kenneth R. Gilmore, Brendan F. Kelly, Stephen A. High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids |
title | High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids |
title_full | High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids |
title_fullStr | High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids |
title_full_unstemmed | High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids |
title_short | High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids |
title_sort | high-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054695/ https://www.ncbi.nlm.nih.gov/pubmed/35520299 http://dx.doi.org/10.1039/d0ra03107k |
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