Enzymatic synthesis of 2-hydroxy-4H-quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS from Huperzia serrata

2-Hydroxy-4H-quinolizin-4-one scaffolds were enzymatically synthesized by integrating three enzymes including phenylacetate-CoA ligase (PcPCL) from an endophytic fungus Penicillium chrysogenum MT-12, malonyl-CoA synthase (AtMatB) from Arabidopsis thaliana, and a type III polyketide synthase (HsPKS3)...

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Detalles Bibliográficos
Autores principales: Wang, Juan, Ding, Ning, Wu, Yun, Shi, Xiaoping, Qi, Bowen, Liu, Xiao, Wang, Xiaohui, Li, Jun, Tu, Pengfei, Shi, Shepo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054772/
https://www.ncbi.nlm.nih.gov/pubmed/35517366
http://dx.doi.org/10.1039/d0ra04133e

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