Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12

Antimicrobial peptides (AMPs) are potential candidates in designing new anti-infective agents. However, many AMPs show poor bactericidal activities in physical salt and serum solutions. Here, we disclosed the structure–function relationships of a novel salt-resistant antimicrobial peptide, RR12, whi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Ping-Sheng, Lai, Shu-Jung, Fung, Kit-Man, Tseng, Tien-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054785/
https://www.ncbi.nlm.nih.gov/pubmed/35517355
http://dx.doi.org/10.1039/d0ra04299d
_version_ 1784697268889190400
author Wu, Ping-Sheng
Lai, Shu-Jung
Fung, Kit-Man
Tseng, Tien-Sheng
author_facet Wu, Ping-Sheng
Lai, Shu-Jung
Fung, Kit-Man
Tseng, Tien-Sheng
author_sort Wu, Ping-Sheng
collection PubMed
description Antimicrobial peptides (AMPs) are potential candidates in designing new anti-infective agents. However, many AMPs show poor bactericidal activities in physical salt and serum solutions. Here, we disclosed the structure–function relationships of a novel salt-resistant antimicrobial peptide, RR12, which could further explain its mode of action and show its applicability in developing new antibacterial agents.
format Online
Article
Text
id pubmed-9054785
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90547852022-05-04 Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12 Wu, Ping-Sheng Lai, Shu-Jung Fung, Kit-Man Tseng, Tien-Sheng RSC Adv Chemistry Antimicrobial peptides (AMPs) are potential candidates in designing new anti-infective agents. However, many AMPs show poor bactericidal activities in physical salt and serum solutions. Here, we disclosed the structure–function relationships of a novel salt-resistant antimicrobial peptide, RR12, which could further explain its mode of action and show its applicability in developing new antibacterial agents. The Royal Society of Chemistry 2020-06-22 /pmc/articles/PMC9054785/ /pubmed/35517355 http://dx.doi.org/10.1039/d0ra04299d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wu, Ping-Sheng
Lai, Shu-Jung
Fung, Kit-Man
Tseng, Tien-Sheng
Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12
title Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12
title_full Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12
title_fullStr Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12
title_full_unstemmed Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12
title_short Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12
title_sort characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, rr12
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054785/
https://www.ncbi.nlm.nih.gov/pubmed/35517355
http://dx.doi.org/10.1039/d0ra04299d
work_keys_str_mv AT wupingsheng characterizationofthestructurefunctionrelationshipofanovelsaltresistantantimicrobialpeptiderr12
AT laishujung characterizationofthestructurefunctionrelationshipofanovelsaltresistantantimicrobialpeptiderr12
AT fungkitman characterizationofthestructurefunctionrelationshipofanovelsaltresistantantimicrobialpeptiderr12
AT tsengtiensheng characterizationofthestructurefunctionrelationshipofanovelsaltresistantantimicrobialpeptiderr12

Ejemplares similares