Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex

Midkine (MDK), a secreted growth factor, regulates signal transduction and cancer progression by interacting with receptors, and it can be internalized into the cytoplasm by endocytosis. However, its intracellular function and signaling regulation remain unclear. Here, we show that intracellular MDK...

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Detalles Bibliográficos
Autores principales: Xia, Tian, Chen, Di, Liu, Xiaolong, Qi, Huan, Wang, Wen, Chen, Huan, Ling, Ting, Otkur, Wuxiyar, Zhang, Chen-Song, Kim, Jongchan, Lin, Sheng-Cai, Piao, Hai-long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054788/
https://www.ncbi.nlm.nih.gov/pubmed/35487917
http://dx.doi.org/10.1038/s41419-022-04801-0

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