Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials

We report the development and use of a light-mediated in situ grafting technology for the surface modification of biosynthetic corneal implants with peptide-capped nanoparticles (15–65 nm). The resulting materials have antimicrobial properties in bacterial suspension and also reduced the extent of b...

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Detalles Bibliográficos
Autores principales: Khatoon, Zohra, Guzmán-Soto, Irene, McTiernan, Christopher D., Lazurko, Caitlin, Simpson, Fiona, Zhang, Li, Cortes, David, Mah, Thien-Fah, Griffith, May, Alarcon, Emilio I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054791/
https://www.ncbi.nlm.nih.gov/pubmed/35517329
http://dx.doi.org/10.1039/d0ra03659e
Descripción
Sumario:We report the development and use of a light-mediated in situ grafting technology for the surface modification of biosynthetic corneal implants with peptide-capped nanoparticles (15–65 nm). The resulting materials have antimicrobial properties in bacterial suspension and also reduced the extent of biofilm formation. Our in situ grafting technology offers a rapid route for the introduction of antimicrobial properties to premoulded corneal implants, and potentially other soft implant targets.

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